Abstract
An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). It was found that gene(s) which map to the K region are involved in regulation of CML response to low-dose TNP-self. It was also found that CML response to TNP recognized in association with H-2D(q) was not detectable in this recombinant. These findings are discussed with respect to the involvement of the H-2K and H-2D regions by structural and/or regulator gene functions.
Original language | English (US) |
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Pages (from-to) | 252-256 |
Number of pages | 5 |
Journal | Journal of Experimental Medicine |
Volume | 151 |
Issue number | 1 |
DOIs | |
State | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology