Abstract
An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). It was found that gene(s) which map to the K region are involved in regulation of CML response to low-dose TNP-self. It was also found that CML response to TNP recognized in association with H-2D(q) was not detectable in this recombinant. These findings are discussed with respect to the involvement of the H-2K and H-2D regions by structural and/or regulator gene functions.
| Original language | English |
|---|---|
| Pages (from-to) | 252-256 |
| Number of pages | 5 |
| Journal | Journal of Experimental Medicine |
| Volume | 151 |
| Issue number | 1 |
| State | Published - Jan 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Regulation of T-cell mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K and H-2D-region genes. / Levy, Robert B; Shearer, G. M.
In: Journal of Experimental Medicine, Vol. 151, No. 1, 01.01.1980, p. 252-256.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Regulation of T-cell mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K and H-2D-region genes
AU - Levy, Robert B
AU - Shearer, G. M.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). It was found that gene(s) which map to the K region are involved in regulation of CML response to low-dose TNP-self. It was also found that CML response to TNP recognized in association with H-2D(q) was not detectable in this recombinant. These findings are discussed with respect to the involvement of the H-2K and H-2D regions by structural and/or regulator gene functions.
AB - An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). It was found that gene(s) which map to the K region are involved in regulation of CML response to low-dose TNP-self. It was also found that CML response to TNP recognized in association with H-2D(q) was not detectable in this recombinant. These findings are discussed with respect to the involvement of the H-2K and H-2D regions by structural and/or regulator gene functions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018858036&partnerID=8YFLogxK
M3 - Article
C2 - 6153113
AN - SCOPUS:0018858036
VL - 151
SP - 252
EP - 256
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 1
ER -