Regulation of T-cell mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K and H-2D-region genes

An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). It was found that gene(s) which map to the K region are involved in regulation of CML response to low-dose TNP-self. It was also found that CML response to TNP recognized in association with H-2D(q) was not detectable in this recombinant. These findings are discussed with respect to the involvement of the H-2K and H-2D regions by structural and/or regulator gene functions.