Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids

Robert B. Dickson, Erik W. Thompson, Marc E. Lippman

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Endogenous ovarian estrogens and progestins appear to play a critical role in the development and progression of breast cancer. Local productions of growth factors probably also contribute to malignant proliferation, while production and activation of collagenolytic enzymes may be equally critical for local invasive processes. The current review focusses on characterization of growth factor-receptor systems operant in normal and malignant breast epithelium. In addition, the determinants of local invasion are reviewed: attachment, modality, and proteose secretion. Finally, data are discussed concerning the regulation of both proliferation and invasion by hormones and antihormonal agents in hormone-dependent breast cancer. The results suggest new potential pharmacologic targets to explore to suppress onset and progression of breast cancer.

Original languageEnglish (US)
Pages (from-to)305-316
Number of pages12
JournalJournal of Steroid Biochemistry and Molecular Biology
Issue number3
StatePublished - Nov 20 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology


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