Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids

Robert B. Dickson, Erik W. Thompson, Marc E Lippman

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Endogenous ovarian estrogens and progestins appear to play a critical role in the development and progression of breast cancer. Local productions of growth factors probably also contribute to malignant proliferation, while production and activation of collagenolytic enzymes may be equally critical for local invasive processes. The current review focusses on characterization of growth factor-receptor systems operant in normal and malignant breast epithelium. In addition, the determinants of local invasion are reviewed: attachment, modality, and proteose secretion. Finally, data are discussed concerning the regulation of both proliferation and invasion by hormones and antihormonal agents in hormone-dependent breast cancer. The results suggest new potential pharmacologic targets to explore to suppress onset and progression of breast cancer.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume37
Issue number3
DOIs
StatePublished - Nov 20 1990
Externally publishedYes

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Intercellular Signaling Peptides and Proteins
Steroids
Hormones
Breast Neoplasms
Growth Factor Receptors
Progestins
Estrogens
Enzyme Activation
Chemical activation
Breast
Enzymes
Epithelium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. / Dickson, Robert B.; Thompson, Erik W.; Lippman, Marc E.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 37, No. 3, 20.11.1990, p. 305-316.

Research output: Contribution to journalArticle

Dickson, Robert B. ; Thompson, Erik W. ; Lippman, Marc E. / Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. In: Journal of Steroid Biochemistry and Molecular Biology. 1990 ; Vol. 37, No. 3. pp. 305-316.
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