Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma

Karina Galoian, Toumy Guettouche, Biju Issac, Amir Qureshi, H. Thomas Temple

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore, the search for new therapies is relevant and urgent. This study aimed to reveal the comparative analysis of miRNAs and their targets in human JJ012 chondrosarcoma cell line between control and experimental samples, treated with mTORC1 inhibitor, cytostatic antiproliferative proline-rich polypeptide (PRP-1). Examination of tumor-specific microRNA expression profiles has revealed widespread deregulation of these molecules in diverse cancers. It was reported that microRNAs can function as novel biomarkers for disease diagnostics and therapy, as well as a novel class of oncogenes and tumor suppressor genes. mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line.

Original languageEnglish
Pages (from-to)2335-2341
Number of pages7
JournalTumor Biology
Volume35
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Chondrosarcoma
MicroRNAs
PRP-1 peptide
Neoplasms
Mesenchymal Chondrosarcoma
Cell Line
Cytostatic Agents
Tumor Suppressor Genes
Oncogenes
Up-Regulation
Down-Regulation
Biomarkers
Radiation
Bone and Bones
Drug Therapy
mechanistic target of rapamycin complex 1
Therapeutics

Keywords

  • Chondrosarcoma
  • MiRNA
  • mTORC1 inhibitor
  • PRP-1

ASJC Scopus subject areas

  • Cancer Research

Cite this

Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma. / Galoian, Karina; Guettouche, Toumy; Issac, Biju; Qureshi, Amir; Thomas Temple, H.

In: Tumor Biology, Vol. 35, No. 3, 01.01.2014, p. 2335-2341.

Research output: Contribution to journalArticle

Galoian, Karina ; Guettouche, Toumy ; Issac, Biju ; Qureshi, Amir ; Thomas Temple, H. / Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma. In: Tumor Biology. 2014 ; Vol. 35, No. 3. pp. 2335-2341.
@article{457995de39ce41d0b189f0409a68196b,
title = "Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma",
abstract = "Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore, the search for new therapies is relevant and urgent. This study aimed to reveal the comparative analysis of miRNAs and their targets in human JJ012 chondrosarcoma cell line between control and experimental samples, treated with mTORC1 inhibitor, cytostatic antiproliferative proline-rich polypeptide (PRP-1). Examination of tumor-specific microRNA expression profiles has revealed widespread deregulation of these molecules in diverse cancers. It was reported that microRNAs can function as novel biomarkers for disease diagnostics and therapy, as well as a novel class of oncogenes and tumor suppressor genes. mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line.",
keywords = "Chondrosarcoma, MiRNA, mTORC1 inhibitor, PRP-1",
author = "Karina Galoian and Toumy Guettouche and Biju Issac and Amir Qureshi and {Thomas Temple}, H.",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s13277-013-1309-7",
language = "English",
volume = "35",
pages = "2335--2341",
journal = "Tumor Biology",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma

AU - Galoian, Karina

AU - Guettouche, Toumy

AU - Issac, Biju

AU - Qureshi, Amir

AU - Thomas Temple, H.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore, the search for new therapies is relevant and urgent. This study aimed to reveal the comparative analysis of miRNAs and their targets in human JJ012 chondrosarcoma cell line between control and experimental samples, treated with mTORC1 inhibitor, cytostatic antiproliferative proline-rich polypeptide (PRP-1). Examination of tumor-specific microRNA expression profiles has revealed widespread deregulation of these molecules in diverse cancers. It was reported that microRNAs can function as novel biomarkers for disease diagnostics and therapy, as well as a novel class of oncogenes and tumor suppressor genes. mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line.

AB - Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore, the search for new therapies is relevant and urgent. This study aimed to reveal the comparative analysis of miRNAs and their targets in human JJ012 chondrosarcoma cell line between control and experimental samples, treated with mTORC1 inhibitor, cytostatic antiproliferative proline-rich polypeptide (PRP-1). Examination of tumor-specific microRNA expression profiles has revealed widespread deregulation of these molecules in diverse cancers. It was reported that microRNAs can function as novel biomarkers for disease diagnostics and therapy, as well as a novel class of oncogenes and tumor suppressor genes. mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line.

KW - Chondrosarcoma

KW - MiRNA

KW - mTORC1 inhibitor

KW - PRP-1

UR - http://www.scopus.com/inward/record.url?scp=84899068109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899068109&partnerID=8YFLogxK

U2 - 10.1007/s13277-013-1309-7

DO - 10.1007/s13277-013-1309-7

M3 - Article

C2 - 24178909

AN - SCOPUS:84899068109

VL - 35

SP - 2335

EP - 2341

JO - Tumor Biology

JF - Tumor Biology

SN - 1010-4283

IS - 3

ER -