Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

Fulvia Verde, Jean Claude Labbé, Marcel Dorée, Eric Karsenti

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of prime importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphasemetaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalNature
Volume343
Issue number6255
StatePublished - Jan 18 1990
Externally publishedYes

Fingerprint

CDC2 Protein Kinase
Xenopus
Cell Extracts
Microtubules
Protein Kinases
Eggs
Transport Vesicles
Interphase
Mitosis
Phosphotransferases
Chromosomes

ASJC Scopus subject areas

  • General

Cite this

Verde, F., Labbé, J. C., Dorée, M., & Karsenti, E. (1990). Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs. Nature, 343(6255), 233-238.

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs. / Verde, Fulvia; Labbé, Jean Claude; Dorée, Marcel; Karsenti, Eric.

In: Nature, Vol. 343, No. 6255, 18.01.1990, p. 233-238.

Research output: Contribution to journalArticle

Verde, F, Labbé, JC, Dorée, M & Karsenti, E 1990, 'Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs', Nature, vol. 343, no. 6255, pp. 233-238.
Verde, Fulvia ; Labbé, Jean Claude ; Dorée, Marcel ; Karsenti, Eric. / Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs. In: Nature. 1990 ; Vol. 343, No. 6255. pp. 233-238.
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