Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

Fulvia Verde, Jean Claude Labbé, Marcel Dorée, Eric Karsenti

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of prime importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphasemetaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalNature
Volume343
Issue number6255
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

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