Abstract
Matrix metalloproteinases (MMPs) are a family of structurally and functionally related zinc-containing endopeptidases that are capable of degrading almost all of the components of the extracellular matrix (ECM). Under physiological and pathological conditions, the MMPs play a significant role in the efficient tissue turnover and remodeling. Specific MMPs are responsible for the matrix degradation and remodeling. Maintenance of the equilibrium between deposition and degradation of the extracellular matrix is essential to the normal tissue development. Therefore, synthesis and breakdown of the MMPs are tightly controlled by protein kinases which mediate a host of other cellular processes. The MMPs are often induced by several agents and any uncontrolled expression of the MMPs can contribute to the pathogenesis of many human diseases. This review focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 1199-1215 |
| Number of pages | 17 |
| Journal | Frontiers in Bioscience |
| Volume | 11 |
| Issue number | 2 P.1199-1590 |
| State | Published - Feb 23 2006 |
| Externally published | Yes |
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Keywords
- Gene expression
- Gene promoter activity
- Matrix metalloproteinases
- Protein kinases
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases. / Reuben, Paul M.; Cheung, Herman S.
In: Frontiers in Bioscience, Vol. 11, No. 2 P.1199-1590, 23.02.2006, p. 1199-1215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases
AU - Reuben, Paul M.
AU - Cheung, Herman S
PY - 2006/2/23
Y1 - 2006/2/23
N2 - Matrix metalloproteinases (MMPs) are a family of structurally and functionally related zinc-containing endopeptidases that are capable of degrading almost all of the components of the extracellular matrix (ECM). Under physiological and pathological conditions, the MMPs play a significant role in the efficient tissue turnover and remodeling. Specific MMPs are responsible for the matrix degradation and remodeling. Maintenance of the equilibrium between deposition and degradation of the extracellular matrix is essential to the normal tissue development. Therefore, synthesis and breakdown of the MMPs are tightly controlled by protein kinases which mediate a host of other cellular processes. The MMPs are often induced by several agents and any uncontrolled expression of the MMPs can contribute to the pathogenesis of many human diseases. This review focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways.
AB - Matrix metalloproteinases (MMPs) are a family of structurally and functionally related zinc-containing endopeptidases that are capable of degrading almost all of the components of the extracellular matrix (ECM). Under physiological and pathological conditions, the MMPs play a significant role in the efficient tissue turnover and remodeling. Specific MMPs are responsible for the matrix degradation and remodeling. Maintenance of the equilibrium between deposition and degradation of the extracellular matrix is essential to the normal tissue development. Therefore, synthesis and breakdown of the MMPs are tightly controlled by protein kinases which mediate a host of other cellular processes. The MMPs are often induced by several agents and any uncontrolled expression of the MMPs can contribute to the pathogenesis of many human diseases. This review focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways.
KW - Gene expression
KW - Gene promoter activity
KW - Matrix metalloproteinases
KW - Protein kinases
KW - Review
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UR - http://www.scopus.com/inward/citedby.url?scp=32844461713&partnerID=8YFLogxK
M3 - Article
C2 - 16368506
AN - SCOPUS:32844461713
VL - 11
SP - 1199
EP - 1215
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - 2 P.1199-1590
ER -