Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation

Sang Yun Nam, Kyong Shin Cho, Young Moon Heo, Jong Cheon Ha, Young Hyun Kim, Ho Keun Yi, Pyong Han Hwang, Hyung Min Kim, Eckhard R. Podack

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


CD30 is expressed transiently on activated B and T lymphocytes and constitutively on several B- and T cell lymphomas. CD30 functions include participation in negative selection of thymocytes, costimulation of activated T cells, isotype switching of B cells, and regulation of the e4ector activity of cytotoxic lymphocytes. Although CD30 is not a marker for T helper 2 (TH2) cells, it may participate in the polarization of TH1 and TH2 cells. The pleiotropic functions of CD30 are initiated by interaction of CD30-expressing cells with other immune competent cells expressing CD30-L and providing the signals for modulation of e4ector cell activity. Here, we report that CD30 signals generated by anti-CD30 on activated, normal murine T cells strongly up-regulate the expression of intercellular adhesion molecule 1 (ICAM-1, CD54), and to a lesser extent, ICAM-2 (CD102). CD30 signals moreover delay the subsequent decline of ICAM expression. CD30 cross-linking did not alter the expression of CD11a/CD18 (LFA-1), the counter receptor for ICAM abundant on T cells. CD30-mediated ICAM-1 up-regulation is independent of cytokine secretion and appears to be transmitted directly through NF-κB activation. CD30-mediated up-regulation of ICAM-1 expression led to a sig-nificant increase in cluster formation of lymph node cells. Increased lymphocyte self-aggregation mediated by CD30 may set the stage for fraternal signaling to modulate lymphocyte function.

Original languageEnglish (US)
Pages (from-to)38-47
Number of pages10
JournalCellular Immunology
Issue number1
StatePublished - 2002
Externally publishedYes


  • Apoptosis
  • Cell surface molecules
  • Cellular activation
  • Costimulation

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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