Regulation of erythropoiesis in the Florida gar, Lepisosteus platyrhincus

Thomas F. McLeod, M. Michael Sigel, Adel A Yunis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

1. 1. The effects of anemia and hypoxia on erythropoiesis in Lepisosteus platyrhincus were examined. 2. 2. Following bleeding, cells morphologically similar to erythroblasts appeared in the circulation and their appearance was paralleled by increases in [14C]δ-aminolevulinic acid and 3H-thymidine uptake by peripheral blood cells. 3. 3. The appearance of heme synthesizing erythroid cells in the circulation could be blocked if the anemia was corrected within 24 hr from bleeding, but not if corrected after 48 hr. 4. 4. Erythropoiesis was not stimulated by hypoxic hypoxia, exposure to carbon monoxide or by drugs that are known to stimulate erythropoiesis in mammals. 5. 5. Alteration of the plasma volume without decreasing red cell mass did not stimulate erythropoiesis.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume60
Issue number2
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Erythropoiesis
Cells
Aminolevulinic Acid
Mammals
Carbon Monoxide
Heme
Thymidine
Anemia
Blood
Erythrocyte Volume
Hemorrhage
Plasmas
Erythroblasts
Erythroid Cells
Plasma Volume
Pharmaceutical Preparations
Blood Cells
Hypoxia

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry
  • Medicine(all)

Cite this

Regulation of erythropoiesis in the Florida gar, Lepisosteus platyrhincus. / McLeod, Thomas F.; Sigel, M. Michael; Yunis, Adel A.

In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 60, No. 2, 1978, p. 145-150.

Research output: Contribution to journalArticle

McLeod, Thomas F. ; Sigel, M. Michael ; Yunis, Adel A. / Regulation of erythropoiesis in the Florida gar, Lepisosteus platyrhincus. In: Comparative Biochemistry and Physiology -- Part A: Physiology. 1978 ; Vol. 60, No. 2. pp. 145-150.
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