Regulation of dynorphin gene expression by κ-opioid agonist treatment

Stephanie Collins; Claudio D'Addario; Patrizia Romualdi; Sanzio Candeletti; Sari Izenwasser

doi:10.1097/00001756-200201210-00025

Regulation of dynorphin gene expression by κ-opioid agonist treatment

Stephanie Collins, Claudio D'Addario, Patrizia Romualdi, Sanzio Candeletti, Sari Izenwasser

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.

Original language	English (US)
Pages (from-to)	107-109
Number of pages	3
Journal	Neuroreport
Volume	13
Issue number	1
DOIs	https://doi.org/10.1097/00001756-200201210-00025
State	Published - Jan 21 2002

Keywords

κ-Opioid receptor
Cocaine
Dynorphin
U-69593

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/00001756-200201210-00025

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title = "Regulation of dynorphin gene expression by κ-opioid agonist treatment",

abstract = "The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.",

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AU - Izenwasser, Sari

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