Regulation of dynorphin gene expression by κ-opioid agonist treatment

Stephanie Collins, Claudio D'Addario, Patrizia Romualdi, Sanzio Candeletti, Sari Izenwasser

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalNeuroreport
Volume13
Issue number1
DOIs
StatePublished - Jan 21 2002

Keywords

  • κ-Opioid receptor
  • Cocaine
  • Dynorphin
  • U-69593

ASJC Scopus subject areas

  • Neuroscience(all)

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