Abstract
The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
| Original language | English |
|---|---|
| Pages (from-to) | 107-109 |
| Number of pages | 3 |
| Journal | NeuroReport |
| Volume | 13 |
| Issue number | 1 |
| State | Published - Jan 21 2002 |
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Keywords
- κ-Opioid receptor
- Cocaine
- Dynorphin
- U-69593
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Regulation of dynorphin gene expression by κ-opioid agonist treatment. / Collins, Stephanie; D'Addario, Claudio; Romualdi, Patrizia; Candeletti, Sanzio; Izenwasser, Sari E.
In: NeuroReport, Vol. 13, No. 1, 21.01.2002, p. 107-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of dynorphin gene expression by κ-opioid agonist treatment
AU - Collins, Stephanie
AU - D'Addario, Claudio
AU - Romualdi, Patrizia
AU - Candeletti, Sanzio
AU - Izenwasser, Sari E
PY - 2002/1/21
Y1 - 2002/1/21
N2 - The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
AB - The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
KW - κ-Opioid receptor
KW - Cocaine
KW - Dynorphin
KW - U-69593
UR - http://www.scopus.com/inward/record.url?scp=0037148173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037148173&partnerID=8YFLogxK
M3 - Article
C2 - 11924869
AN - SCOPUS:0037148173
VL - 13
SP - 107
EP - 109
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 1
ER -