Abstract
The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-109 |
| Number of pages | 3 |
| Journal | Neuroreport |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 21 2002 |
Keywords
- κ-Opioid receptor
- Cocaine
- Dynorphin
- U-69593
ASJC Scopus subject areas
- Neuroscience(all)
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Collins, S., D'Addario, C., Romualdi, P., Candeletti, S., & Izenwasser, S. (2002). Regulation of dynorphin gene expression by κ-opioid agonist treatment. Neuroreport, 13(1), 107-109. https://doi.org/10.1097/00001756-200201210-00025