Regulation of dynorphin gene expression by κ-opioid agonist treatment

Stephanie Collins, Claudio D'Addario, Patrizia Romualdi, Sanzio Candeletti, Sari E Izenwasser

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of κ-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that κ-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalNeuroReport
Volume13
Issue number1
StatePublished - Jan 21 2002

Fingerprint

Dynorphins
Gene Expression Regulation
Opioid Analgesics
Messenger RNA
Frontal Lobe
Hypothalamus
Therapeutics
Injections
Opioid Receptors
Hippocampus
preproenkephalin
Brain
U 69593

Keywords

  • κ-Opioid receptor
  • Cocaine
  • Dynorphin
  • U-69593

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Collins, S., D'Addario, C., Romualdi, P., Candeletti, S., & Izenwasser, S. E. (2002). Regulation of dynorphin gene expression by κ-opioid agonist treatment. NeuroReport, 13(1), 107-109.

Regulation of dynorphin gene expression by κ-opioid agonist treatment. / Collins, Stephanie; D'Addario, Claudio; Romualdi, Patrizia; Candeletti, Sanzio; Izenwasser, Sari E.

In: NeuroReport, Vol. 13, No. 1, 21.01.2002, p. 107-109.

Research output: Contribution to journalArticle

Collins, S, D'Addario, C, Romualdi, P, Candeletti, S & Izenwasser, SE 2002, 'Regulation of dynorphin gene expression by κ-opioid agonist treatment', NeuroReport, vol. 13, no. 1, pp. 107-109.
Collins S, D'Addario C, Romualdi P, Candeletti S, Izenwasser SE. Regulation of dynorphin gene expression by κ-opioid agonist treatment. NeuroReport. 2002 Jan 21;13(1):107-109.
Collins, Stephanie ; D'Addario, Claudio ; Romualdi, Patrizia ; Candeletti, Sanzio ; Izenwasser, Sari E. / Regulation of dynorphin gene expression by κ-opioid agonist treatment. In: NeuroReport. 2002 ; Vol. 13, No. 1. pp. 107-109.
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