Regulation of chromatin structure by long noncoding RNAs

Focus on natural antisense transcripts

Marco Magistri, Mohammad A Faghihi, Georges St Laurent, Claes R Wahlestedt

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

In the decade following the publication of the Human Genome, noncoding RNAs (ncRNAs) have reshaped our understanding of the broad landscape of genome regulation. During this period, natural antisense transcripts (NATs), which are transcribed from the opposite strand of either protein or non-protein coding genes, have vaulted to prominence. Recent findings have shown that NATs can exert their regulatory functions by acting as epigenetic regulators of gene expression and chromatin remodeling. Here, we review recent work on the mechanisms of epigenetic modifications by NATs and their emerging role as master regulators of chromatin states. Unlike other long ncRNAs, antisense RNAs usually regulate their counterpart sense mRNA in cis by bridging epigenetic effectors and regulatory complexes at specific genomic loci. Understanding the broad range of effects of NATs will shed light on the complex mechanisms that regulate chromatin remodeling and gene expression in development and disease.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalTrends in Genetics
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2012

Fingerprint

Long Noncoding RNA
Epigenomics
Chromatin
Chromatin Assembly and Disassembly
Gene Expression
Antisense RNA
Untranslated RNA
Human Genome
Regulator Genes
Publications
Genome
Messenger RNA
Genes
Proteins

Keywords

  • Antisense RNA
  • Chromatin
  • Epigenetics
  • NATs
  • NcRNAs
  • Transcriptome

ASJC Scopus subject areas

  • Genetics

Cite this

Regulation of chromatin structure by long noncoding RNAs : Focus on natural antisense transcripts. / Magistri, Marco; Faghihi, Mohammad A; St Laurent, Georges; Wahlestedt, Claes R.

In: Trends in Genetics, Vol. 28, No. 8, 01.08.2012, p. 389-396.

Research output: Contribution to journalArticle

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