Regulation of angiogenesis by microRNAs in cardiovascular diseases

Devika Kir, Erica Schnettler, Shrey Modi, Sundaram Ramakrishnan

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Non-coding RNAs are functional RNA molecules comprising the majority of human transcriptome. Only about 1.5% of the human genome is transcribed into messenger RNAs (mRNA) that are translated into proteins. Among the non-coding RNAs, miRNAs are extensively studied and miR targets in endothelial cells, perivascular cells, and angiogenic signaling are relatively well defined. MicroRNAs not only regulate transcripts in situ but also function as paracrine mediators in affecting angiogenesis at distant sites. Exosomal miRs are implicated in modulating endothelial cell function and angiogenesis. Thus miRs have been shown to affect tissue microenvironment in a multitude of ways. A comprehensive analysis of the role of miRs in modulation of angiogenesis and their impact on cardiovascular diseases is presented in this review.

Original languageEnglish (US)
Pages (from-to)699-710
Number of pages12
JournalAngiogenesis
Volume21
Issue number4
DOIs
StatePublished - Nov 1 2018

Keywords

  • Angiogenesis
  • Cardiovascular
  • lncRNA
  • MI
  • MicroRNA
  • Non-coding RNA
  • Therapeutics

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cancer Research

Fingerprint Dive into the research topics of 'Regulation of angiogenesis by microRNAs in cardiovascular diseases'. Together they form a unique fingerprint.

Cite this