Regulation of an insect symbiosis

Alex C.C. Wilson

doi:10.1016/bs.aiip.2020.04.004

Regulation of an insect symbiosis

Alex C.C. Wilson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The best studied insect nutritional endosymbiosis is that of aphids and Buchnera aphidicola. Work on the aphid/Buchnera model has uncovered multiple regulatory systems within this symbiosis that include gene losses, genome rearrangements, complementary metabolic pathways, feedback inhibition loops involving amino acid transporters, miRNAs, small RNAs as well as a conserved growth pathway. Taken together, this work on how an endosymbiont is integrated into its host at a cellular and molecular level challenges the idea of a harmonious mutualism. Here I describe each of the known regulatory systems in the aphid/Buchnera model of endosymbiosis, offer some new interpretations, highlight knowledge gaps and conclude by arguing that the evolution of host/endosymbiont integration is littered with signatures of conflict.

Original language	English (US)
Title of host publication	Advances in Insect Physiology
Publisher	Academic Press Inc.
DOIs	https://doi.org/10.1016/bs.aiip.2020.04.004
State	Accepted/In press - 2020
Externally published	Yes

Publication series

Name	Advances in Insect Physiology
ISSN (Print)	0065-2806
ISSN (Electronic)	2213-6800

Keywords

Aphid
Buchnera
Conflict
Endosymbiosis
Host/endosymbiont integration
Regulation
TOR
mTOR

ASJC Scopus subject areas

Insect Science

Access to Document

10.1016/bs.aiip.2020.04.004

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title = "Regulation of an insect symbiosis",

abstract = "The best studied insect nutritional endosymbiosis is that of aphids and Buchnera aphidicola. Work on the aphid/Buchnera model has uncovered multiple regulatory systems within this symbiosis that include gene losses, genome rearrangements, complementary metabolic pathways, feedback inhibition loops involving amino acid transporters, miRNAs, small RNAs as well as a conserved growth pathway. Taken together, this work on how an endosymbiont is integrated into its host at a cellular and molecular level challenges the idea of a harmonious mutualism. Here I describe each of the known regulatory systems in the aphid/Buchnera model of endosymbiosis, offer some new interpretations, highlight knowledge gaps and conclude by arguing that the evolution of host/endosymbiont integration is littered with signatures of conflict.",

keywords = "Aphid, Buchnera, Conflict, Endosymbiosis, Host/endosymbiont integration, Regulation, TOR, mTOR",

author = "Wilson, {Alex C.C.}",

note = "Funding Information: The writing of this chapter benefited from useful discussions with many people, including my current and former students, Edward James, Celeste Banfill, Honglin Feng, Rebecca Duncan, and my colleagues, J. David Van Dyken and Hsiao-ling Lu. Hsiao-ling Lu was especially generous in providing the confocal images included in Fig. 1 . This chapter was additionally improved by the input of an anonymous reviewer (you know who you are—thank you), and the editors of this volume, Jake Russell and Kerry Oliver, who continue to inspire me with their abilities to pull our community together to produce work like this volume. The preparation of this review was supported by National Science Foundation Award IOS-1354154. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

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KW - mTOR

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