@inbook{3b853c58426d4323a57187be90f417a3,
title = "Regulation of an insect symbiosis",
abstract = "The best studied insect nutritional endosymbiosis is that of aphids and Buchnera aphidicola. Work on the aphid/Buchnera model has uncovered multiple regulatory systems within this symbiosis that include gene losses, genome rearrangements, complementary metabolic pathways, feedback inhibition loops involving amino acid transporters, miRNAs, small RNAs as well as a conserved growth pathway. Taken together, this work on how an endosymbiont is integrated into its host at a cellular and molecular level challenges the idea of a harmonious mutualism. Here I describe each of the known regulatory systems in the aphid/Buchnera model of endosymbiosis, offer some new interpretations, highlight knowledge gaps and conclude by arguing that the evolution of host/endosymbiont integration is littered with signatures of conflict.",
keywords = "Aphid, Buchnera, Conflict, Endosymbiosis, Host/endosymbiont integration, Regulation, TOR, mTOR",
author = "Wilson, {Alex C.C.}",
note = "Funding Information: The writing of this chapter benefited from useful discussions with many people, including my current and former students, Edward James, Celeste Banfill, Honglin Feng, Rebecca Duncan, and my colleagues, J. David Van Dyken and Hsiao-ling Lu. Hsiao-ling Lu was especially generous in providing the confocal images included in Fig. 1 . This chapter was additionally improved by the input of an anonymous reviewer (you know who you are—thank you), and the editors of this volume, Jake Russell and Kerry Oliver, who continue to inspire me with their abilities to pull our community together to produce work like this volume. The preparation of this review was supported by National Science Foundation Award IOS-1354154. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1016/bs.aiip.2020.04.004",
language = "English (US)",
series = "Advances in Insect Physiology",
publisher = "Academic Press Inc.",
booktitle = "Advances in Insect Physiology",
}