Regulation of acetylcholine synthesis

does cytoplasmic acetylcholine control high affinity choline uptake?

D. J. Jenden, Richard S Jope, M. H. Weiler

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

Original languageEnglish
Pages (from-to)635-637
Number of pages3
JournalScience
Volume194
Issue number4265
StatePublished - Dec 1 1976
Externally publishedYes

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Choline
Acetylcholine
Synaptosomes
Cholinergic Agents
Brain

ASJC Scopus subject areas

  • General

Cite this

Regulation of acetylcholine synthesis : does cytoplasmic acetylcholine control high affinity choline uptake? / Jenden, D. J.; Jope, Richard S; Weiler, M. H.

In: Science, Vol. 194, No. 4265, 01.12.1976, p. 635-637.

Research output: Contribution to journalArticle

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