Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?

Donald J. Jenden; Richard S. Jope; Molly H. Weiler

doi:10.1126/science.982031

Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?

Donald J. Jenden, Richard S. Jope, Molly H. Weiler

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

When brain synaptosomes are obtained from animals that have been injected intravenously with [²H₄]choline 1 minute before being killed, their high affinity [³H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [²H₄] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

Original language	English (US)
Pages (from-to)	635-637
Number of pages	3
Journal	Science
Volume	194
Issue number	4265
DOIs	https://doi.org/10.1126/science.982031
State	Published - Jan 1 1976
Externally published	Yes

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title = "Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?",

abstract = "When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.",

author = "Jenden, {Donald J.} and Jope, {Richard S.} and Weiler, {Molly H.}",

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