Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?

D. J. Jenden, Richard S Jope, M. H. Weiler

Research output: Contribution to journalArticle

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Abstract

When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

Original languageEnglish
Pages (from-to)635-637
Number of pages3
JournalScience
Volume194
Issue number4265
StatePublished - Dec 1 1976
Externally publishedYes

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