Abstract
When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
| Original language | English |
|---|---|
| Pages (from-to) | 635-637 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 194 |
| Issue number | 4265 |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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Cite this
Regulation of acetylcholine synthesis : does cytoplasmic acetylcholine control high affinity choline uptake? / Jenden, D. J.; Jope, Richard S; Weiler, M. H.
In: Science, Vol. 194, No. 4265, 01.12.1976, p. 635-637.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of acetylcholine synthesis
T2 - does cytoplasmic acetylcholine control high affinity choline uptake?
AU - Jenden, D. J.
AU - Jope, Richard S
AU - Weiler, M. H.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
AB - When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
UR - http://www.scopus.com/inward/record.url?scp=0017092259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017092259&partnerID=8YFLogxK
M3 - Article
VL - 194
SP - 635
EP - 637
JO - Science
JF - Science
SN - 0036-8075
IS - 4265
ER -