Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?

Donald J. Jenden; Richard S. Jope; Molly H. Weiler

doi:10.1126/science.982031

Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?

Donald J. Jenden, Richard S. Jope, Molly H. Weiler

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

When brain synaptosomes are obtained from animals that have been injected intravenously with [²H₄]choline 1 minute before being killed, their high affinity [³H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [²H₄] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

Original language	English (US)
Pages (from-to)	635-637
Number of pages	3
Journal	Science
Volume	194
Issue number	4265
DOIs	https://doi.org/10.1126/science.982031
State	Published - 1976
Externally published	Yes

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@article{52647060a32348458a9018682fcf2185,

title = "Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?",

abstract = "When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.",

author = "Jenden, {Donald J.} and Jope, {Richard S.} and Weiler, {Molly H.}",

year = "1976",

doi = "10.1126/science.982031",

language = "English (US)",

volume = "194",

pages = "635--637",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4265",

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TY - JOUR

T1 - Regulation of acetylcholine synthesis

T2 - Does cytoplasmic acetylcholine control high affinity choline uptake?

AU - Jenden, Donald J.

AU - Jope, Richard S.

AU - Weiler, Molly H.

PY - 1976

Y1 - 1976

N2 - When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

AB - When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

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U2 - 10.1126/science.982031

DO - 10.1126/science.982031

M3 - Article

C2 - 982031

AN - SCOPUS:0017092259

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SP - 635

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JO - Science

JF - Science

SN - 0036-8075

IS - 4265

ER -

Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake?

Abstract

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