Abstract
When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
Original language | English (US) |
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Pages (from-to) | 635-637 |
Number of pages | 3 |
Journal | Science |
Volume | 194 |
Issue number | 4265 |
DOIs | |
State | Published - Jan 1 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- General