Abstract
When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4] acetylcholine. The control of such choline uptake by the cytoplasmic acetycholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 635-637 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 194 |
| Issue number | 4265 |
| DOIs | |
| State | Published - Jan 1 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Cite this
Jenden, D. J., Jope, R. S., & Weiler, M. H. (1976). Regulation of acetylcholine synthesis: Does cytoplasmic acetylcholine control high affinity choline uptake? Science, 194(4265), 635-637. https://doi.org/10.1126/science.982031