Regulation of β-cell mass and function by the Akt/protein kinase B signalling pathway

L. Elghazi, L. Rachdi, A. J. Weiss, C. Cras-Méneur, Ernesto Bernal-Mizrachi

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The insulin receptor substrate-2/phosphoinositide 3-kinase (PI3K) pathway plays a critical role in the regulation of β-cell mass and function, demonstrated both in vitro and in vivo. The serine threonine kinase Akt is one of the promising downstream molecules of this pathway that has been identified as a potential target to regulate function and induce proliferation and survival of β cells. Here we summarize some of the molecular mechanisms, downstream signalling pathways and critical components involved in the regulation of β-cell mass and function by Akt.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalDiabetes, Obesity and Metabolism
Volume9
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Akt
  • Apoptosis
  • Diabetes
  • GSK3
  • IRS1
  • IRS2
  • PI3K
  • PKB
  • Pancreatic islets
  • mTOR
  • β-cell mass
  • β-cell proliferation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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