Regulation by Ca2+ in the Yersinia low-Ca2+ response

Susan C. Straley, Gregory V Plano, Elz̈bieta Skrzypek, Pryce L. Haddix, Kenneth A. Fields

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The Yersinia low-Ca2+ response (LCR) is a regulatory response in which a set of plasmid-borne operons is transcriptionally regulated at 37°C in response to the presence or absence of mM concentrations of Ca2+. LCR-regulated operons encode secreted proteins with regulatory and virulence roles as well as non-secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane-bound inductive components. An important role in LCR induction is played by LcrD, an innermembrane protein with homologues in several virulence-associated and flagella assembly-related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalMolecular Microbiology
Volume8
Issue number6
StatePublished - Jun 1 1993
Externally publishedYes

Fingerprint

Yersinia
Operon
Proteins
Virulence
Down-Regulation
Flagella
Signal Transduction
Plasmids
Membranes
DNA

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology

Cite this

Straley, S. C., Plano, G. V., Skrzypek, E., Haddix, P. L., & Fields, K. A. (1993). Regulation by Ca2+ in the Yersinia low-Ca2+ response. Molecular Microbiology, 8(6), 1005-1010.

Regulation by Ca2+ in the Yersinia low-Ca2+ response. / Straley, Susan C.; Plano, Gregory V; Skrzypek, Elz̈bieta; Haddix, Pryce L.; Fields, Kenneth A.

In: Molecular Microbiology, Vol. 8, No. 6, 01.06.1993, p. 1005-1010.

Research output: Contribution to journalArticle

Straley, SC, Plano, GV, Skrzypek, E, Haddix, PL & Fields, KA 1993, 'Regulation by Ca2+ in the Yersinia low-Ca2+ response', Molecular Microbiology, vol. 8, no. 6, pp. 1005-1010.
Straley SC, Plano GV, Skrzypek E, Haddix PL, Fields KA. Regulation by Ca2+ in the Yersinia low-Ca2+ response. Molecular Microbiology. 1993 Jun 1;8(6):1005-1010.
Straley, Susan C. ; Plano, Gregory V ; Skrzypek, Elz̈bieta ; Haddix, Pryce L. ; Fields, Kenneth A. / Regulation by Ca2+ in the Yersinia low-Ca2+ response. In: Molecular Microbiology. 1993 ; Vol. 8, No. 6. pp. 1005-1010.
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