Regulated heparin release using novel quantum dots for potential application to vascular graft engineering

Sang Jin Lee, Benjamin Harrison, Richard Czerw, James J. Yoo, Anthony Atala, Jeong Ok Lim

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.

Original languageEnglish (US)
Pages (from-to)1191-1198
Number of pages8
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2009

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Keywords

  • External regulation
  • Heparin
  • NIR energy
  • Polymeric controlled release
  • Quantum dot
  • Tissue engineering
  • Vascular graft

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Ceramics and Composites
  • Chemistry(all)

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