Regulated heparin release using novel quantum dots for potential application to vascular graft engineering

Sang Jin Lee, Benjamin Harrison, Richard Czerw, James J. Yoo, Anthony Atala, Jeong Ok Lim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.

Original languageEnglish
Pages (from-to)1191-1198
Number of pages8
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Fingerprint

Grafts
Semiconductor quantum dots
Heparin
Irradiation
Pharmaceutical Preparations
Capsules
Controlled drug delivery
Blood vessels
Infrared radiation

Keywords

  • External regulation
  • Heparin
  • NIR energy
  • Polymeric controlled release
  • Quantum dot
  • Tissue engineering
  • Vascular graft

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Ceramics and Composites
  • Chemistry(all)

Cite this

Regulated heparin release using novel quantum dots for potential application to vascular graft engineering. / Lee, Sang Jin; Harrison, Benjamin; Czerw, Richard; Yoo, James J.; Atala, Anthony; Lim, Jeong Ok.

In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 46, No. 12, 01.12.2009, p. 1191-1198.

Research output: Contribution to journalArticle

Lee, Sang Jin ; Harrison, Benjamin ; Czerw, Richard ; Yoo, James J. ; Atala, Anthony ; Lim, Jeong Ok. / Regulated heparin release using novel quantum dots for potential application to vascular graft engineering. In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2009 ; Vol. 46, No. 12. pp. 1191-1198.
@article{846690157b394f5fa3ccc3c12490b81c,
title = "Regulated heparin release using novel quantum dots for potential application to vascular graft engineering",
abstract = "This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.",
keywords = "External regulation, Heparin, NIR energy, Polymeric controlled release, Quantum dot, Tissue engineering, Vascular graft",
author = "Lee, {Sang Jin} and Benjamin Harrison and Richard Czerw and Yoo, {James J.} and Anthony Atala and Lim, {Jeong Ok}",
year = "2009",
month = "12",
day = "1",
doi = "10.1080/10601320903340150",
language = "English",
volume = "46",
pages = "1191--1198",
journal = "Journal of Macromolecular Science - Pure and Applied Chemistry",
issn = "1060-1325",
publisher = "Taylor and Francis Ltd.",
number = "12",

}

TY - JOUR

T1 - Regulated heparin release using novel quantum dots for potential application to vascular graft engineering

AU - Lee, Sang Jin

AU - Harrison, Benjamin

AU - Czerw, Richard

AU - Yoo, James J.

AU - Atala, Anthony

AU - Lim, Jeong Ok

PY - 2009/12/1

Y1 - 2009/12/1

N2 - This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.

AB - This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.

KW - External regulation

KW - Heparin

KW - NIR energy

KW - Polymeric controlled release

KW - Quantum dot

KW - Tissue engineering

KW - Vascular graft

UR - http://www.scopus.com/inward/record.url?scp=70449361848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449361848&partnerID=8YFLogxK

U2 - 10.1080/10601320903340150

DO - 10.1080/10601320903340150

M3 - Article

VL - 46

SP - 1191

EP - 1198

JO - Journal of Macromolecular Science - Pure and Applied Chemistry

JF - Journal of Macromolecular Science - Pure and Applied Chemistry

SN - 1060-1325

IS - 12

ER -