Regulated cutaneous gene delivery: The skin as a bioreactor

Tongyu Wikramanayake, X. J. Wang, D. R. Roop

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic delivery of transgene products. Here we review the development of epidermal secretory systems, from cultured keratinocytes to skin grafts and transgenic mouse models. We also discuss a gene-switch approach for regulated cutaneous gene delivery.

Original languageEnglish
Pages (from-to)2297-2300
Number of pages4
JournalHuman Gene Therapy
Volume11
Issue number16
DOIs
StatePublished - Nov 1 2000
Externally publishedYes

Fingerprint

Bioreactors
Keratinocytes
Skin
Switch Genes
Genes
Transgenes
Transgenic Mice
Transplants
Peptides

ASJC Scopus subject areas

  • Genetics

Cite this

Regulated cutaneous gene delivery : The skin as a bioreactor. / Wikramanayake, Tongyu; Wang, X. J.; Roop, D. R.

In: Human Gene Therapy, Vol. 11, No. 16, 01.11.2000, p. 2297-2300.

Research output: Contribution to journalArticle

Wikramanayake, Tongyu ; Wang, X. J. ; Roop, D. R. / Regulated cutaneous gene delivery : The skin as a bioreactor. In: Human Gene Therapy. 2000 ; Vol. 11, No. 16. pp. 2297-2300.
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