Regulated cutaneous gene delivery: The skin as a bioreactor

T. Cao, X. J. Wang, D. R. Roop

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic delivery of transgene products. Here we review the development of epidermal secretory systems, from cultured keratinocytes to skin grafts and transgenic mouse models. We also discuss a gene-switch approach for regulated cutaneous gene delivery.

Original languageEnglish (US)
Pages (from-to)2297-2300
Number of pages4
JournalHuman gene therapy
Issue number16
StatePublished - Nov 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics


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