Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

Ilias G. Kirkinezos; Dayami Hernandez; Walter G. Bradley; Carlos T. Moraes

doi:10.1002/ana.10597

Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

Ilias G. Kirkinezos, Dayami Hernandez, Walter G. Bradley, Carlos T. Moraes

Neurology

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131 Scopus citations

Abstract

We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.

Original language	English (US)
Pages (from-to)	804-807
Number of pages	4
Journal	Annals of neurology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1002/ana.10597
State	Published - Jun 1 2003

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.",

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AU - Moraes, Carlos T.

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Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

Abstract

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