Abstract
We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 804-807 |
| Number of pages | 4 |
| Journal | Annals of neurology |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2003 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
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Cite this
Kirkinezos, I. G., Hernandez, D., Bradley, W. G., & Moraes, C. T. (2003). Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Annals of neurology, 53(6), 804-807. https://doi.org/10.1002/ana.10597