Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

Ilias G. Kirkinezos, Dayami Hernandez, Walter G. Bradley, Carlos T. Moraes

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.

Original languageEnglish (US)
Pages (from-to)804-807
Number of pages4
JournalAnnals of neurology
Volume53
Issue number6
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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