Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography

Shuliang Jiao, Chunyan Wu, Robert W. Knighton, Giovanni Gregori, Carmen A. Puliafito

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We previously developed a technique to acquire a SLO (scanning laser ophthalmoscope) like fundus intensity image from the raw spectra measured with spectral-domain optical coherence tomography (OCT), the same spectra used to generate a 3D OCT data set. This technique offers simultaneous fundus and OCT images and, therefore, solves the problem of registering a cross sectional OCT image to fundus features. However, the registration of high density OCT images is still an unsolved problem because no useful fundus image can be generated from the high density scans. High density OCT images can significantly improve the image quality and enhance the visualization of retinal structure, especially the structure of small lesions. We have developed a feature-based algorithm, which can register a high density OCT image on the fundus image generated from normal density scans. The algorithm was successfully tested for both normal and diseased eyes.

Original languageEnglish (US)
Pages (from-to)3368-3376
Number of pages9
JournalOptics Express
Volume14
Issue number8
DOIs
StatePublished - Apr 17 2006

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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