Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats

Patricia L. Kozlovskis, J. D. Silver, R. W. Rubin, S. S. Wong, M. S. Gaide, A. L. Bassett, J. S. Cameron, R. J. Myerburg

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.

Original languageEnglish (US)
Pages (from-to)559-566
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume16
Issue number6
DOIs
StatePublished - Jun 1984

Keywords

  • Cardiac myosin concentration
  • Myocardial hypertrophy
  • Myocardial infarction healed
  • Myosin heavy chain

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats'. Together they form a unique fingerprint.

  • Cite this