Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats

Patricia L. Kozlovskis; J. D. Silver; R. W. Rubin; S. S. Wong; M. S. Gaide; A. L. Bassett; J. S. Cameron; R. J. Myerburg

doi:10.1016/S0022-2828(84)80642-2

Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats

Patricia L. Kozlovskis, J. D. Silver, R. W. Rubin, S. S. Wong, M. S. Gaide, A. L. Bassett, J. S. Cameron, R. J. Myerburg

Medicine

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.

Original language	English (US)
Pages (from-to)	559-566
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/S0022-2828(84)80642-2
State	Published - Jun 1984

Keywords

Cardiac myosin concentration
Myocardial hypertrophy
Myocardial infarction healed
Myosin heavy chain

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/S0022-2828(84)80642-2

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Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats. / Kozlovskis, Patricia L.; Silver, J. D.; Rubin, R. W.; Wong, S. S.; Gaide, M. S.; Bassett, A. L.; Cameron, J. S.; Myerburg, R. J.

In: Journal of Molecular and Cellular Cardiology, Vol. 16, No. 6, 06.1984, p. 559-566.

Research output: Contribution to journal › Review article › peer-review

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title = "Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats",

abstract = "Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.",

keywords = "Cardiac myosin concentration, Myocardial hypertrophy, Myocardial infarction healed, Myosin heavy chain",

author = "Kozlovskis, {Patricia L.} and Silver, {J. D.} and Rubin, {R. W.} and Wong, {S. S.} and Gaide, {M. S.} and Bassett, {A. L.} and Cameron, {J. S.} and Myerburg, {R. J.}",

note = "Funding Information: This work supported by NIH research grants HL 21735 and HL 19044; training grant HL 07436 (Dr Kozlovskis); a grant from the American Heart Association, Greater Miami Chapter, the Veterans Administration Medical Center, Miami, Florida and BRSG, RR05363-21. We thank Joyce Keck for preparation of the manuscript.",

year = "1984",

month = jun,

doi = "10.1016/S0022-2828(84)80642-2",

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AU - Kozlovskis, Patricia L.

AU - Silver, J. D.

AU - Rubin, R. W.

AU - Wong, S. S.

AU - Gaide, M. S.

AU - Bassett, A. L.

AU - Cameron, J. S.

AU - Myerburg, R. J.

N1 - Funding Information: This work supported by NIH research grants HL 21735 and HL 19044; training grant HL 07436 (Dr Kozlovskis); a grant from the American Heart Association, Greater Miami Chapter, the Veterans Administration Medical Center, Miami, Florida and BRSG, RR05363-21. We thank Joyce Keck for preparation of the manuscript.

PY - 1984/6

Y1 - 1984/6

N2 - Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.

AB - Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.

KW - Cardiac myosin concentration

KW - Myocardial hypertrophy

KW - Myocardial infarction healed

KW - Myosin heavy chain

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