Abstract
Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.
| Original language | English |
|---|---|
| Pages (from-to) | 559-566 |
| Number of pages | 8 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1984 |
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Keywords
- Cardiac myosin concentration
- Myocardial hypertrophy
- Myocardial infarction healed
- Myosin heavy chain
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats. / Kozlovskis, Patricia L.; Silver, J. D.; Rubin, R. W.; Wong, S. S.; Gaide, M. S.; Bassett, A. L.; Cameron, J. S.; Myerburg, Robert J.
In: Journal of Molecular and Cellular Cardiology, Vol. 16, No. 6, 01.01.1984, p. 559-566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats
AU - Kozlovskis, Patricia L.
AU - Silver, J. D.
AU - Rubin, R. W.
AU - Wong, S. S.
AU - Gaide, M. S.
AU - Bassett, A. L.
AU - Cameron, J. S.
AU - Myerburg, Robert J
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.
AB - Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat heart 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.
KW - Cardiac myosin concentration
KW - Myocardial hypertrophy
KW - Myocardial infarction healed
KW - Myosin heavy chain
UR - http://www.scopus.com/inward/record.url?scp=0021605360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021605360&partnerID=8YFLogxK
U2 - 10.1016/S0022-2828(84)80642-2
DO - 10.1016/S0022-2828(84)80642-2
M3 - Article
C2 - 6748090
AN - SCOPUS:0021605360
VL - 16
SP - 559
EP - 566
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - 6
ER -