Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population

Joshua Z. Willey, Yeseon P. Moon, Mandip S. Dhamoon, Erin R. Kulick, Ahmet Bagci, Noam Alperin, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S.V. Elkind

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale. Methods: The SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score. Results: Among 668 participants with SPPB measurements (mean 74 ± 9 years, 37% male and 70% Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = –0.3 per SD, p = 0.001), anterior periventricular (beta = –0.4 per SD, p = 0.001), parietal (beta = –0.2 per SD, p = 0.02) and frontal (beta = –0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB. Conclusions: WMHV, especially in the anterior ­cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalNeuroepidemiology
DOIs
StateAccepted/In press - Jun 28 2018

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Cerebrovascular Disorders
Population
Brain
White Matter
Hispanic Americans
Linear Models

Keywords

  • Balance
  • Magnetic resonance imaging
  • White matter hyperintensities

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Willey, J. Z., Moon, Y. P., Dhamoon, M. S., Kulick, E. R., Bagci, A., Alperin, N., ... Elkind, M. S. V. (Accepted/In press). Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population. Neuroepidemiology, 57-63. https://doi.org/10.1159/000490351

Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population. / Willey, Joshua Z.; Moon, Yeseon P.; Dhamoon, Mandip S.; Kulick, Erin R.; Bagci, Ahmet; Alperin, Noam; Cheung, Ying Kuen; Wright, Clinton B; Sacco, Ralph L; Elkind, Mitchell S.V.

In: Neuroepidemiology, 28.06.2018, p. 57-63.

Research output: Contribution to journalArticle

Willey, Joshua Z. ; Moon, Yeseon P. ; Dhamoon, Mandip S. ; Kulick, Erin R. ; Bagci, Ahmet ; Alperin, Noam ; Cheung, Ying Kuen ; Wright, Clinton B ; Sacco, Ralph L ; Elkind, Mitchell S.V. / Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population. In: Neuroepidemiology. 2018 ; pp. 57-63.
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abstract = "Introduction: White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale. Methods: The SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score. Results: Among 668 participants with SPPB measurements (mean 74 ± 9 years, 37{\%} male and 70{\%} Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = –0.3 per SD, p = 0.001), anterior periventricular (beta = –0.4 per SD, p = 0.001), parietal (beta = –0.2 per SD, p = 0.02) and frontal (beta = –0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB. Conclusions: WMHV, especially in the anterior ­cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.",
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AU - Moon, Yeseon P.

AU - Dhamoon, Mandip S.

AU - Kulick, Erin R.

AU - Bagci, Ahmet

AU - Alperin, Noam

AU - Cheung, Ying Kuen

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AU - Sacco, Ralph L

AU - Elkind, Mitchell S.V.

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N2 - Introduction: White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale. Methods: The SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score. Results: Among 668 participants with SPPB measurements (mean 74 ± 9 years, 37% male and 70% Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = –0.3 per SD, p = 0.001), anterior periventricular (beta = –0.4 per SD, p = 0.001), parietal (beta = –0.2 per SD, p = 0.02) and frontal (beta = –0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB. Conclusions: WMHV, especially in the anterior ­cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.

AB - Introduction: White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale. Methods: The SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score. Results: Among 668 participants with SPPB measurements (mean 74 ± 9 years, 37% male and 70% Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = –0.3 per SD, p = 0.001), anterior periventricular (beta = –0.4 per SD, p = 0.001), parietal (beta = –0.2 per SD, p = 0.02) and frontal (beta = –0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB. Conclusions: WMHV, especially in the anterior ­cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.

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