Regional sensitivity to verapamil in ventricular myocardium

John S. Cameron, Samuel S. Wong, Marion S. Gaide, Robert J. Myerburg, Kristina Epstein, Arthur L. Bassett

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effects of verapamil (0.1-4.0 μg/ml) on transmembrane action potential configuration was examined in various regions of the normal cat left ventricular endocardium. Surface electrograms showed that the sequence of activation of anterior papillary muscle fibers was from the base of the muscle to its apex, while overlying Purkinje fibers were activated in the opposite direction. Action potential duration in basal muscle fibers was relatively unaffected by verapamil, while cells at the tip of the papillary muscle showed increased slope in phase 2 and a more rapid rate of early repolarization. Regional sensitivity to verapamil may reflect disparate patterns of endocardial activation, and could influence the effectiveness of the drug against ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalEuropean Journal of Pharmacology
Volume90
Issue number2-3
DOIs
StatePublished - Jun 3 1983

Keywords

  • Action potential duration
  • Endocardial activation
  • Ventricular muscle fibers
  • Verapamil

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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    Cameron, J. S., Wong, S. S., Gaide, M. S., Myerburg, R. J., Epstein, K., & Bassett, A. L. (1983). Regional sensitivity to verapamil in ventricular myocardium. European Journal of Pharmacology, 90(2-3), 283-287. https://doi.org/10.1016/0014-2999(83)90251-0