Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T

Helen Maghsudi, Birte Schmitz, Andrew A Maudsley, Sulaiman Sheriff, Paul Bronzlik, Martin Schütze, Heinrich Lanfermann, Xiaoqi Ding

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The aim of this study was to compare a recently established whole brain MR spectroscopic imaging (wbMRSI) technique using spin-echo planar spectroscopic imaging (EPSI) acquisition and the Metabolic Imaging and Data Analysis System (MIDAS) software package with single voxel spectroscopy (SVS) technique and LCModel analysis for determination of relative metabolite concentrations in aging human brain. Methods: A total of 59 healthy subjects aged 20–70 years (n ≥ 5 per age decade for each gender) underwent a wbEPSI scan and 3 SVS scans of a 4 ml voxel volume located in the right basal ganglia, occipital grey matter and parietal white matter. Concentration ratios to total creatine (tCr) for N‑acetylaspartate (NAA/tCr), total choline (tCho/tCr), glutamine (Gln/tCr), glutamate (Glu/tCr) and myoinositol (mI/tCr) were obtained both from EPSI and SVS acquisitions with either LCModel or MIDAS. In addition, an aqueous phantom containing known metabolite concentrations was also measured. Results: Metabolite concentrations obtained with wbMRSI and SVS were comparable and consistent with those reported previously. Decreases of NAA/tCr and increases of line width with age were found with both techniques, while the results obtained from EPSI acquisition revealed generally narrower line widths and smaller Cramer-Rao lower bounds than those from SVS data. Conclusion: The wbMRSI could be used to estimate metabolites in vivo and in vitro with the same reliability as using SVS, with the main advantage being the ability to determine metabolite concentrations in multiple brain structure simultaneously in vivo. It is expected to be widely used in clinical diagnostics and neuroscience.

Original languageEnglish (US)
JournalClinical Neuroradiology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Creatine
Spectrum Analysis
Echo-Planar Imaging
Brain
Information Systems
Inositol
Neurosciences
Choline
Basal Ganglia
Glutamine
Glutamic Acid
Healthy Volunteers
Software

Keywords

  • Aging
  • Metabolic Imaging and Data Analysis System
  • Spin-echo planar spectroscopic imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Regional Metabolite Concentrations in Aging Human Brain : Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T. / Maghsudi, Helen; Schmitz, Birte; Maudsley, Andrew A; Sheriff, Sulaiman; Bronzlik, Paul; Schütze, Martin; Lanfermann, Heinrich; Ding, Xiaoqi.

In: Clinical Neuroradiology, 01.01.2019.

Research output: Contribution to journalArticle

Maghsudi, Helen ; Schmitz, Birte ; Maudsley, Andrew A ; Sheriff, Sulaiman ; Bronzlik, Paul ; Schütze, Martin ; Lanfermann, Heinrich ; Ding, Xiaoqi. / Regional Metabolite Concentrations in Aging Human Brain : Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T. In: Clinical Neuroradiology. 2019.
@article{b60bcacab6a04224a8af588573c6a10d,
title = "Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T",
abstract = "Purpose: The aim of this study was to compare a recently established whole brain MR spectroscopic imaging (wbMRSI) technique using spin-echo planar spectroscopic imaging (EPSI) acquisition and the Metabolic Imaging and Data Analysis System (MIDAS) software package with single voxel spectroscopy (SVS) technique and LCModel analysis for determination of relative metabolite concentrations in aging human brain. Methods: A total of 59 healthy subjects aged 20–70 years (n ≥ 5 per age decade for each gender) underwent a wbEPSI scan and 3 SVS scans of a 4 ml voxel volume located in the right basal ganglia, occipital grey matter and parietal white matter. Concentration ratios to total creatine (tCr) for N‑acetylaspartate (NAA/tCr), total choline (tCho/tCr), glutamine (Gln/tCr), glutamate (Glu/tCr) and myoinositol (mI/tCr) were obtained both from EPSI and SVS acquisitions with either LCModel or MIDAS. In addition, an aqueous phantom containing known metabolite concentrations was also measured. Results: Metabolite concentrations obtained with wbMRSI and SVS were comparable and consistent with those reported previously. Decreases of NAA/tCr and increases of line width with age were found with both techniques, while the results obtained from EPSI acquisition revealed generally narrower line widths and smaller Cramer-Rao lower bounds than those from SVS data. Conclusion: The wbMRSI could be used to estimate metabolites in vivo and in vitro with the same reliability as using SVS, with the main advantage being the ability to determine metabolite concentrations in multiple brain structure simultaneously in vivo. It is expected to be widely used in clinical diagnostics and neuroscience.",
keywords = "Aging, Metabolic Imaging and Data Analysis System, Spin-echo planar spectroscopic imaging",
author = "Helen Maghsudi and Birte Schmitz and Maudsley, {Andrew A} and Sulaiman Sheriff and Paul Bronzlik and Martin Sch{\"u}tze and Heinrich Lanfermann and Xiaoqi Ding",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00062-018-00757-x",
language = "English (US)",
journal = "Clinical Neuroradiology",
issn = "1869-1439",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Regional Metabolite Concentrations in Aging Human Brain

T2 - Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T

AU - Maghsudi, Helen

AU - Schmitz, Birte

AU - Maudsley, Andrew A

AU - Sheriff, Sulaiman

AU - Bronzlik, Paul

AU - Schütze, Martin

AU - Lanfermann, Heinrich

AU - Ding, Xiaoqi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: The aim of this study was to compare a recently established whole brain MR spectroscopic imaging (wbMRSI) technique using spin-echo planar spectroscopic imaging (EPSI) acquisition and the Metabolic Imaging and Data Analysis System (MIDAS) software package with single voxel spectroscopy (SVS) technique and LCModel analysis for determination of relative metabolite concentrations in aging human brain. Methods: A total of 59 healthy subjects aged 20–70 years (n ≥ 5 per age decade for each gender) underwent a wbEPSI scan and 3 SVS scans of a 4 ml voxel volume located in the right basal ganglia, occipital grey matter and parietal white matter. Concentration ratios to total creatine (tCr) for N‑acetylaspartate (NAA/tCr), total choline (tCho/tCr), glutamine (Gln/tCr), glutamate (Glu/tCr) and myoinositol (mI/tCr) were obtained both from EPSI and SVS acquisitions with either LCModel or MIDAS. In addition, an aqueous phantom containing known metabolite concentrations was also measured. Results: Metabolite concentrations obtained with wbMRSI and SVS were comparable and consistent with those reported previously. Decreases of NAA/tCr and increases of line width with age were found with both techniques, while the results obtained from EPSI acquisition revealed generally narrower line widths and smaller Cramer-Rao lower bounds than those from SVS data. Conclusion: The wbMRSI could be used to estimate metabolites in vivo and in vitro with the same reliability as using SVS, with the main advantage being the ability to determine metabolite concentrations in multiple brain structure simultaneously in vivo. It is expected to be widely used in clinical diagnostics and neuroscience.

AB - Purpose: The aim of this study was to compare a recently established whole brain MR spectroscopic imaging (wbMRSI) technique using spin-echo planar spectroscopic imaging (EPSI) acquisition and the Metabolic Imaging and Data Analysis System (MIDAS) software package with single voxel spectroscopy (SVS) technique and LCModel analysis for determination of relative metabolite concentrations in aging human brain. Methods: A total of 59 healthy subjects aged 20–70 years (n ≥ 5 per age decade for each gender) underwent a wbEPSI scan and 3 SVS scans of a 4 ml voxel volume located in the right basal ganglia, occipital grey matter and parietal white matter. Concentration ratios to total creatine (tCr) for N‑acetylaspartate (NAA/tCr), total choline (tCho/tCr), glutamine (Gln/tCr), glutamate (Glu/tCr) and myoinositol (mI/tCr) were obtained both from EPSI and SVS acquisitions with either LCModel or MIDAS. In addition, an aqueous phantom containing known metabolite concentrations was also measured. Results: Metabolite concentrations obtained with wbMRSI and SVS were comparable and consistent with those reported previously. Decreases of NAA/tCr and increases of line width with age were found with both techniques, while the results obtained from EPSI acquisition revealed generally narrower line widths and smaller Cramer-Rao lower bounds than those from SVS data. Conclusion: The wbMRSI could be used to estimate metabolites in vivo and in vitro with the same reliability as using SVS, with the main advantage being the ability to determine metabolite concentrations in multiple brain structure simultaneously in vivo. It is expected to be widely used in clinical diagnostics and neuroscience.

KW - Aging

KW - Metabolic Imaging and Data Analysis System

KW - Spin-echo planar spectroscopic imaging

UR - http://www.scopus.com/inward/record.url?scp=85060190118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060190118&partnerID=8YFLogxK

U2 - 10.1007/s00062-018-00757-x

DO - 10.1007/s00062-018-00757-x

M3 - Article

AN - SCOPUS:85060190118

JO - Clinical Neuroradiology

JF - Clinical Neuroradiology

SN - 1869-1439

ER -