Regional lymphadenectomy and tumor immunity

W. J. Pendergrast, M. S. Soloway, G. H. Myers, J. W. Futrell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study sought to determine if tumor immunity was impaired by regional lymphadenectomy when performed at different stages of tumor growth. Regional lymphadenectomy significantly reduced tumor specific immunity when performed soon after tumor inoculation. However, removal of the regional lymph nodes later but before the tumor was clinically detectable did not affect the development of tumor immunity. Similarly, regional lymphadenectomy after the tumor was palpable did not decrease tumor immunity. Therefore, prior to the time that the tumor is clinically detectable, immunologic sensitization has become a systemic phenomenon and is no longer confined to the regional lymph nodes.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalSurgery Gynecology and Obstetrics
Volume142
Issue number3
StatePublished - Dec 1 1976
Externally publishedYes

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Lymph Node Excision
Immunity
Neoplasms
Lymph Nodes
Immunization
Growth

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Pendergrast, W. J., Soloway, M. S., Myers, G. H., & Futrell, J. W. (1976). Regional lymphadenectomy and tumor immunity. Surgery Gynecology and Obstetrics, 142(3), 385-390.

Regional lymphadenectomy and tumor immunity. / Pendergrast, W. J.; Soloway, M. S.; Myers, G. H.; Futrell, J. W.

In: Surgery Gynecology and Obstetrics, Vol. 142, No. 3, 01.12.1976, p. 385-390.

Research output: Contribution to journalArticle

Pendergrast, WJ, Soloway, MS, Myers, GH & Futrell, JW 1976, 'Regional lymphadenectomy and tumor immunity', Surgery Gynecology and Obstetrics, vol. 142, no. 3, pp. 385-390.
Pendergrast WJ, Soloway MS, Myers GH, Futrell JW. Regional lymphadenectomy and tumor immunity. Surgery Gynecology and Obstetrics. 1976 Dec 1;142(3):385-390.
Pendergrast, W. J. ; Soloway, M. S. ; Myers, G. H. ; Futrell, J. W. / Regional lymphadenectomy and tumor immunity. In: Surgery Gynecology and Obstetrics. 1976 ; Vol. 142, No. 3. pp. 385-390.
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