Regional isolation-perfusion: An experimental percutaneous approach tested and compared with arterial occlusion-infusion

Kenneth C. Wright, Chusilp Charnsangavej, Sidney Wallace, Vincent P. Chuang, Niramol Savaraj

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A percutaneous approach was developed for the performance of regional isolation-perfusion, a surgical chemotherapeutic procedure for the intraarterial treatment of neoplasms. This technique was compared with percutaneous transcatheter arterial occlusion-infusion concerning local and systemic drug levels. Floxuridine (FUDR) was administered into a femoral artery of adult mongrel dogs, first by arterial occlusion-infusion, and 4 weeks later by regional isolation-perfusion of the opposite hind limb. Local and systemic plasma samples and local muscle specimens were collected for determination of FUDR levels. Results indicated not only that regional isolation-perfusion could be accomplished percutaneously, using balloon catheters, but also that the technique produced significantly greater local tissue FUDR levels (P < 0.05) than those achieved with arterial occlusion-infusion.

Original languageEnglish (US)
Pages (from-to)294-298
Number of pages5
JournalCardioVascular and Interventional Radiology
Volume7
Issue number6
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

Keywords

  • Chemotherapy, intraarterial, regional
  • Floxuridine
  • Isolation-Perfusion
  • Occlusion-Infusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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