Regional isolation-perfusion: An experimental percutaneous approach tested and compared with arterial occlusion-infusion

Kenneth C. Wright; Chusilp Charnsangavej; Sidney Wallace; Vincent P. Chuang; Niramol Savaraj

doi:10.1007/BF02625114

Regional isolation-perfusion: An experimental percutaneous approach tested and compared with arterial occlusion-infusion

Kenneth C. Wright, Chusilp Charnsangavej, Sidney Wallace, Vincent P. Chuang, Niramol Savaraj

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A percutaneous approach was developed for the performance of regional isolation-perfusion, a surgical chemotherapeutic procedure for the intraarterial treatment of neoplasms. This technique was compared with percutaneous transcatheter arterial occlusion-infusion concerning local and systemic drug levels. Floxuridine (FUDR) was administered into a femoral artery of adult mongrel dogs, first by arterial occlusion-infusion, and 4 weeks later by regional isolation-perfusion of the opposite hind limb. Local and systemic plasma samples and local muscle specimens were collected for determination of FUDR levels. Results indicated not only that regional isolation-perfusion could be accomplished percutaneously, using balloon catheters, but also that the technique produced significantly greater local tissue FUDR levels (P < 0.05) than those achieved with arterial occlusion-infusion.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Cardiovascular and Interventional Radiology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1007/BF02625114
State	Published - Dec 1984

Keywords

Chemotherapy, intraarterial, regional
Floxuridine
Isolation-Perfusion
Occlusion-Infusion

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/BF02625114

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Regional isolation-perfusion : An experimental percutaneous approach tested and compared with arterial occlusion-infusion. / Wright, Kenneth C.; Charnsangavej, Chusilp; Wallace, Sidney; Chuang, Vincent P.; Savaraj, Niramol.

In: Cardiovascular and Interventional Radiology, Vol. 7, No. 6, 12.1984, p. 294-298.

Research output: Contribution to journal › Article › peer-review

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