Abstract
A percutaneous approach was developed for the performance of regional isolation-perfusion, a surgical chemotherapeutic procedure for the intraarterial treatment of neoplasms. This technique was compared with percutaneous transcatheter arterial occlusion-infusion concerning local and systemic drug levels. Floxuridine (FUDR) was administered into a femoral artery of adult mongrel dogs, first by arterial occlusion-infusion, and 4 weeks later by regional isolation-perfusion of the opposite hind limb. Local and systemic plasma samples and local muscle specimens were collected for determination of FUDR levels. Results indicated not only that regional isolation-perfusion could be accomplished percutaneously, using balloon catheters, but also that the technique produced significantly greater local tissue FUDR levels (P < 0.05) than those achieved with arterial occlusion-infusion.
Original language | English (US) |
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Pages (from-to) | 294-298 |
Number of pages | 5 |
Journal | Cardiovascular and Interventional Radiology |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1984 |
Keywords
- Chemotherapy, intraarterial, regional
- Floxuridine
- Isolation-Perfusion
- Occlusion-Infusion
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine