Regional Distribution of Neurotensin in Human Brain

Paul J. Manberg, William W. Youngblood, Charles B. Nemeroff, Martin N. Rossor, Leslie L. Iversen, Arthur J. Prange, John S. Kizer

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Neurotensin (NT) is an endogenous neuropeptide that is active in many preclinical screening tests for neuroleptic drugs. Using a radioimmunoassay, we have studied the regional distribution of NT in postmortem human brain and in cerebrospinal fluid. Highest levels were present in the hypothalamus, substantia nigra, and limbic areas, whereas much lower amounts were found in the cortex and striatum. The chromatographic properties of hypothalamic immunoreactivity on ion-exchange and high pressure liquid chromatography were similar to those of the synthetic tridecapeptide. We conclude that NT is present in human brain with a distribution resembling that seen in other species, such as rat and monkey.

Original languageEnglish (US)
Pages (from-to)1777-1780
Number of pages4
JournalJournal of neurochemistry
Volume38
Issue number6
DOIs
StatePublished - Jun 1982
Externally publishedYes

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Keywords

  • HPLC
  • Human distribution
  • Neuropeptide
  • Neurotensin
  • RIA

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Manberg, P. J., Youngblood, W. W., Nemeroff, C. B., Rossor, M. N., Iversen, L. L., Prange, A. J., & Kizer, J. S. (1982). Regional Distribution of Neurotensin in Human Brain. Journal of neurochemistry, 38(6), 1777-1780. https://doi.org/10.1111/j.1471-4159.1982.tb06664.x