Regional distribution of cyclic GMP and its metabolizing enzymes within the hippocampal formation of the guinea-pig

P. E. Kilbride, W. D. Dietrich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Using quantitative histochemical methods the distribution of cyclic GMP, guanylate cyclase and cyclic GMP phosphodiesterase among regions of the guinea-pig hippocampal formation was examined. The four regions examined were the dentate gyrus, hippocampus, subiculum and entorhinal cortex. The guanylate cyclase activity was lowest in the hippocampus and only half that of the other regions which had similar activity. In contrast, cyclic GMP phosphodiesterase activity varied little among the four regions. Basal cyclic GMP content was similar in hippocampus, subiculum and entorhinal cortex; however, the dentate gyrus had nearly twice this basal level. Seizures produced by pentylenetetrazol treatment caused a variable (4-7-fold) increase in levels of cyclic GMP in all the regions. The hippocampus had the lowest level of cyclic GMP during seizure activity. This may be the result of the lower guanylate cyclase in the hippocampus as compared to the other regions studied.

Original languageEnglish (US)
Pages (from-to)991-993
Number of pages3
JournalNeuropharmacology
Volume20
Issue number10
DOIs
StatePublished - Oct 1981
Externally publishedYes

Keywords

  • cyclic GMP
  • cyclic GMP phosphodiesterase
  • guanylate cyclase
  • guinea-pig
  • hippocampal formation
  • pentylenetetrazol
  • seizure

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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