Regional differences in the timing of synapse elimination in skeletal muscles of the neonatal rabbit

John L. Bixby; D. C. Van Essen

doi:10.1016/0006-8993(79)91030-8

Regional differences in the timing of synapse elimination in skeletal muscles of the neonatal rabbit

John L. Bixby, D. C. Van Essen

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The time course of disappearance of polyneuronal innervation during development was studied electrophysiologically in skeletal muscles of the rabbit. There were differences of up to a week in the estimated time of onset of synapse elimination in various muscles, with a tendency for the process to begin earlier in muscles situated more anteriorly in the body. There were also differences among muscles in the peak rate of synapse loss during maturation, but these differences do not appear to be related to position in the body or to contractile properties of the muscle.

Original language	English (US)
Pages (from-to)	275-286
Number of pages	12
Journal	Brain research
Volume	169
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(79)91030-8
State	Published - Jun 22 1979
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Regional differences in the timing of synapse elimination in skeletal muscles of the neonatal rabbit",

abstract = "The time course of disappearance of polyneuronal innervation during development was studied electrophysiologically in skeletal muscles of the rabbit. There were differences of up to a week in the estimated time of onset of synapse elimination in various muscles, with a tendency for the process to begin earlier in muscles situated more anteriorly in the body. There were also differences among muscles in the peak rate of synapse loss during maturation, but these differences do not appear to be related to position in the body or to contractile properties of the muscle.",

author = "Bixby, {John L.} and {Van Essen}, {D. C.}",

note = "Funding Information: We thank J. P. Brockes and D. P. Corey for useful comments on the manuscript, A. J. Hudspeth for criticism, and E. Hanson for typing the manuscript. This project was supported by BRSG Grant RR07003 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health.",

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doi = "10.1016/0006-8993(79)91030-8",

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T1 - Regional differences in the timing of synapse elimination in skeletal muscles of the neonatal rabbit

AU - Bixby, John L.

AU - Van Essen, D. C.

N1 - Funding Information: We thank J. P. Brockes and D. P. Corey for useful comments on the manuscript, A. J. Hudspeth for criticism, and E. Hanson for typing the manuscript. This project was supported by BRSG Grant RR07003 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health.

PY - 1979/6/22

Y1 - 1979/6/22

N2 - The time course of disappearance of polyneuronal innervation during development was studied electrophysiologically in skeletal muscles of the rabbit. There were differences of up to a week in the estimated time of onset of synapse elimination in various muscles, with a tendency for the process to begin earlier in muscles situated more anteriorly in the body. There were also differences among muscles in the peak rate of synapse loss during maturation, but these differences do not appear to be related to position in the body or to contractile properties of the muscle.

AB - The time course of disappearance of polyneuronal innervation during development was studied electrophysiologically in skeletal muscles of the rabbit. There were differences of up to a week in the estimated time of onset of synapse elimination in various muscles, with a tendency for the process to begin earlier in muscles situated more anteriorly in the body. There were also differences among muscles in the peak rate of synapse loss during maturation, but these differences do not appear to be related to position in the body or to contractile properties of the muscle.

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