Abstract
Sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated cardriving task following oral administration of dchlorpheniramine using positron emission tomography (PET) and [15O]H2O. Healthy volunteers drove a car in a simulated environment following oral administration of a sedative antihistamine, d-chlorpheniramine, or placebo. Their rCBF was measured in the conditions of resting, active driving, and passive driving. Performance evaluation revealed that the number of lane deviations significantly increased in the dchlorpheniramine condition (p<0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses were detected following d-chlorpheniramine treatment in the parietal, temporal and visual cortices and in the cerebellum. These results suggest that d-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordination even when the subjects do not recognize subjective feeling of sedation.
| Original language | English (US) |
|---|---|
| Title of host publication | 13th International Conference on Biomedical Engineering - ICBME 2008 |
| Pages | 2201-2203 |
| Number of pages | 3 |
| Volume | 23 |
| DOIs | |
| State | Published - Dec 1 2009 |
| Externally published | Yes |
| Event | 13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore Duration: Dec 3 2008 → Dec 6 2008 |
Other
| Other | 13th International Conference on Biomedical Engineering, ICBME 2008 |
|---|---|
| Country | Singapore |
| Period | 12/3/08 → 12/6/08 |
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Keywords
- driving performance
- Positron emission tomography (PET)
- regional cerebral blood flow (rCBF)
- sedative antihistamine
ASJC Scopus subject areas
- Biomedical Engineering
- Bioengineering
Cite this
Regional Brain Activity and Performance During Car-Driving Under Side Effects of Psychoactive Drugs. / Tashiro, Manabu; Masud Mehedi, M. D.; Jeong, Myeonggi; Sakurada, Yumiko; Mochizuki, Hideki; Horikawa, Etsuo; Kato, Motohisa; Maruyama, Masahiro; Okamura, Nobuyuki; Watanuki, Shoichi; Arai, Hiroyuki; Itoh, Masatoshi; Yanai, Kazuhiko.
13th International Conference on Biomedical Engineering - ICBME 2008. Vol. 23 2009. p. 2201-2203.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Regional Brain Activity and Performance During Car-Driving Under Side Effects of Psychoactive Drugs
AU - Tashiro, Manabu
AU - Masud Mehedi, M. D.
AU - Jeong, Myeonggi
AU - Sakurada, Yumiko
AU - Mochizuki, Hideki
AU - Horikawa, Etsuo
AU - Kato, Motohisa
AU - Maruyama, Masahiro
AU - Okamura, Nobuyuki
AU - Watanuki, Shoichi
AU - Arai, Hiroyuki
AU - Itoh, Masatoshi
AU - Yanai, Kazuhiko
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated cardriving task following oral administration of dchlorpheniramine using positron emission tomography (PET) and [15O]H2O. Healthy volunteers drove a car in a simulated environment following oral administration of a sedative antihistamine, d-chlorpheniramine, or placebo. Their rCBF was measured in the conditions of resting, active driving, and passive driving. Performance evaluation revealed that the number of lane deviations significantly increased in the dchlorpheniramine condition (p<0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses were detected following d-chlorpheniramine treatment in the parietal, temporal and visual cortices and in the cerebellum. These results suggest that d-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordination even when the subjects do not recognize subjective feeling of sedation.
AB - Sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated cardriving task following oral administration of dchlorpheniramine using positron emission tomography (PET) and [15O]H2O. Healthy volunteers drove a car in a simulated environment following oral administration of a sedative antihistamine, d-chlorpheniramine, or placebo. Their rCBF was measured in the conditions of resting, active driving, and passive driving. Performance evaluation revealed that the number of lane deviations significantly increased in the dchlorpheniramine condition (p<0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses were detected following d-chlorpheniramine treatment in the parietal, temporal and visual cortices and in the cerebellum. These results suggest that d-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordination even when the subjects do not recognize subjective feeling of sedation.
KW - driving performance
KW - Positron emission tomography (PET)
KW - regional cerebral blood flow (rCBF)
KW - sedative antihistamine
UR - http://www.scopus.com/inward/record.url?scp=84891949625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891949625&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-92841-6_551
DO - 10.1007/978-3-540-92841-6_551
M3 - Conference contribution
AN - SCOPUS:84891949625
SN - 9783540928409
VL - 23
SP - 2201
EP - 2203
BT - 13th International Conference on Biomedical Engineering - ICBME 2008
ER -