Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging

Norbert Schuff, Frank Ezekiel, Anthony C. Gamst, Diane L. Amend, Andres A. Capizzano, Andrew A Maudsley, M. W. Weiner

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Quantitative measurements of regional and tissue specific concentrations of brain metabolites were measured in elderly subjects using multislice proton magnetic resonance spectroscopic imaging (1H MRSI). Selective k-space extrapolation and an inversion-recovery sequence were used to minimize lipid contamination and linear regression was used to account for partial volume problems. The technique was applied to measure the concentrations of N-acetyl aspartate (NAA), and creatine (Cr)- and choline (Cho)-containing compounds in cortical gray and white matter, and white matter lesions of the frontal and the parietal lobe in 40 normal elderly subjects (22 females and 18 males, 56-89 years old, mean age 74 ± 8). NAA was about 15% lower in cortical gray matter and 23% lower in white matter lesions when compared to normal white matter. Cr was 11% higher in cortical gray matter than in white matter, and also about 15% higher in the parietal cortex than in the frontal cortex. Cho was 28% lower in cortical gray matter than in white matter. Furthermore, NAA and Cr changes correlated with age. In conclusion, regional and tissue differences of brain metabolites must be considered in addition to age-related changes when interpreting 1H MRSI data.

Original languageEnglish
Pages (from-to)899-907
Number of pages9
JournalMagnetic Resonance in Medicine
Volume45
Issue number5
DOIs
StatePublished - May 15 2001
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Creatine
Brain
Parietal Lobe
Frontal Lobe
Choline
Sequence Inversion
White Matter
Protons
Linear Models
Lipids
Gray Matter
N-acetylaspartate

Keywords

  • Aging
  • Gray and white matter
  • Magnetic resonance spectroscopic imaging
  • Quantification
  • White matter lesions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. / Schuff, Norbert; Ezekiel, Frank; Gamst, Anthony C.; Amend, Diane L.; Capizzano, Andres A.; Maudsley, Andrew A; Weiner, M. W.

In: Magnetic Resonance in Medicine, Vol. 45, No. 5, 15.05.2001, p. 899-907.

Research output: Contribution to journalArticle

Schuff, Norbert ; Ezekiel, Frank ; Gamst, Anthony C. ; Amend, Diane L. ; Capizzano, Andres A. ; Maudsley, Andrew A ; Weiner, M. W. / Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. In: Magnetic Resonance in Medicine. 2001 ; Vol. 45, No. 5. pp. 899-907.
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