Regenerative medicine strategies for treating neurogenic bladder

James J. Yoo, Jennifer Olson, Anthony Atala, Bupwan Kim

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Neurogenic bladder is a general term encompassing various neurologic dysfunctions of the bladder and the external urethral sphincter. These can be caused by damage or disease. Therapeutic management options can be conservative, minimally invasive, or surgical. The current standard for surgical management is bladder augmentation using intestinal segments. However, because intestinal tissue possesses different functional characteristics than bladder tissue, numerous complications can ensue, including excess mucus production, urinary stone formation, and malignancy. As a result, investigators have sought after alternative solutions. Tissue engineering is a scientific field that uses combinations of cells and biomaterials to encourage regeneration of new, healthy tissue and offers an alternative approach for the replacement of lost or deficient organs, including the bladder. Promising results using tissue-engineered bladder have already been obtained in children with neurogenic bladder caused by myelomeningocele. Human clinical trials, governed by the Food and Drug Administration, are ongoing in the United States in both children and adults to further evaluate the safety and efficacy of this technology. This review will introduce the principles of tissue engineering and discuss how it can be used to treat refractory cases of neurogenic bladder.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalInternational Neurourology Journal
Volume15
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Biomaterials
  • Reconstruction
  • Regenerative medicine
  • Tissue engineering
  • Urinary bladder

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology
  • Neurology

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