Abstract
The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.
| Original language | English |
|---|---|
| Pages (from-to) | 867-880 |
| Number of pages | 14 |
| Journal | Annals of Surgery |
| Volume | 255 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Regenerative medicine as applied to general surgery. / Orlando, Giuseppe; Wood, Kathryn J.; De Coppi, Paolo; Baptista, Pedro M.; Binder, Kyle W.; Bitar, Khalil N.; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H.; Koch, Kenneth; MacChiarini, Paolo; Sani, Sayed Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M.; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J.; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J.; Soker, Shay.
In: Annals of Surgery, Vol. 255, No. 5, 01.05.2012, p. 867-880.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regenerative medicine as applied to general surgery
AU - Orlando, Giuseppe
AU - Wood, Kathryn J.
AU - De Coppi, Paolo
AU - Baptista, Pedro M.
AU - Binder, Kyle W.
AU - Bitar, Khalil N.
AU - Breuer, Christopher
AU - Burnett, Luke
AU - Christ, George
AU - Farney, Alan
AU - Figliuzzi, Marina
AU - Holmes, James H.
AU - Koch, Kenneth
AU - MacChiarini, Paolo
AU - Sani, Sayed Hadi Mirmalek
AU - Opara, Emmanuel
AU - Remuzzi, Andrea
AU - Rogers, Jeffrey
AU - Saul, Justin M.
AU - Seliktar, Dror
AU - Shapira-Schweitzer, Keren
AU - Smith, Tom
AU - Solomon, Daniel
AU - Van Dyke, Mark
AU - Yoo, James J.
AU - Zhang, Yuanyuan
AU - Atala, Anthony
AU - Stratta, Robert J.
AU - Soker, Shay
PY - 2012/5/1
Y1 - 2012/5/1
N2 - The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.
AB - The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.
UR - http://www.scopus.com/inward/record.url?scp=84862777058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862777058&partnerID=8YFLogxK
U2 - 10.1097/SLA.0b013e318243a4db
DO - 10.1097/SLA.0b013e318243a4db
M3 - Article
VL - 255
SP - 867
EP - 880
JO - Annals of Surgery
JF - Annals of Surgery
SN - 0003-4932
IS - 5
ER -