Regenerative medicine as applied to general surgery

Giuseppe Orlando, Kathryn J. Wood, Paolo De Coppi, Pedro M. Baptista, Kyle W. Binder, Khalil N. Bitar, Christopher Breuer, Luke Burnett, George Christ, Alan Farney, Marina Figliuzzi, James H. Holmes, Kenneth Koch, Paolo MacChiarini, Sayed Hadi Mirmalek Sani, Emmanuel Opara, Andrea Remuzzi, Jeffrey Rogers, Justin M. Saul, Dror Seliktar & 9 others Keren Shapira-Schweitzer, Tom Smith, Daniel Solomon, Mark Van Dyke, James J. Yoo, Yuanyuan Zhang, Anthony Atala, Robert J. Stratta, Shay Soker

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.

Original languageEnglish
Pages (from-to)867-880
Number of pages14
JournalAnnals of Surgery
Volume255
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Regenerative Medicine
Cell Physiological Phenomena
Biocompatible Materials
Human Body
Blood Vessels
Research Personnel
Clinical Trials

ASJC Scopus subject areas

  • Surgery

Cite this

Orlando, G., Wood, K. J., De Coppi, P., Baptista, P. M., Binder, K. W., Bitar, K. N., ... Soker, S. (2012). Regenerative medicine as applied to general surgery. Annals of Surgery, 255(5), 867-880. https://doi.org/10.1097/SLA.0b013e318243a4db

Regenerative medicine as applied to general surgery. / Orlando, Giuseppe; Wood, Kathryn J.; De Coppi, Paolo; Baptista, Pedro M.; Binder, Kyle W.; Bitar, Khalil N.; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H.; Koch, Kenneth; MacChiarini, Paolo; Sani, Sayed Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M.; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J.; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J.; Soker, Shay.

In: Annals of Surgery, Vol. 255, No. 5, 01.05.2012, p. 867-880.

Research output: Contribution to journalArticle

Orlando, G, Wood, KJ, De Coppi, P, Baptista, PM, Binder, KW, Bitar, KN, Breuer, C, Burnett, L, Christ, G, Farney, A, Figliuzzi, M, Holmes, JH, Koch, K, MacChiarini, P, Sani, SHM, Opara, E, Remuzzi, A, Rogers, J, Saul, JM, Seliktar, D, Shapira-Schweitzer, K, Smith, T, Solomon, D, Van Dyke, M, Yoo, JJ, Zhang, Y, Atala, A, Stratta, RJ & Soker, S 2012, 'Regenerative medicine as applied to general surgery', Annals of Surgery, vol. 255, no. 5, pp. 867-880. https://doi.org/10.1097/SLA.0b013e318243a4db
Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN et al. Regenerative medicine as applied to general surgery. Annals of Surgery. 2012 May 1;255(5):867-880. https://doi.org/10.1097/SLA.0b013e318243a4db
Orlando, Giuseppe ; Wood, Kathryn J. ; De Coppi, Paolo ; Baptista, Pedro M. ; Binder, Kyle W. ; Bitar, Khalil N. ; Breuer, Christopher ; Burnett, Luke ; Christ, George ; Farney, Alan ; Figliuzzi, Marina ; Holmes, James H. ; Koch, Kenneth ; MacChiarini, Paolo ; Sani, Sayed Hadi Mirmalek ; Opara, Emmanuel ; Remuzzi, Andrea ; Rogers, Jeffrey ; Saul, Justin M. ; Seliktar, Dror ; Shapira-Schweitzer, Keren ; Smith, Tom ; Solomon, Daniel ; Van Dyke, Mark ; Yoo, James J. ; Zhang, Yuanyuan ; Atala, Anthony ; Stratta, Robert J. ; Soker, Shay. / Regenerative medicine as applied to general surgery. In: Annals of Surgery. 2012 ; Vol. 255, No. 5. pp. 867-880.
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