Regenerative medicine as applied to general surgery

Giuseppe Orlando; Kathryn J. Wood; Paolo De Coppi; Pedro M. Baptista; Kyle W. Binder; Khalil N. Bitar; Christopher Breuer; Luke Burnett; George Christ; Alan Farney; Marina Figliuzzi; James H. Holmes; Kenneth Koch; Paolo MacChiarini; Sayed Hadi Mirmalek Sani; Emmanuel Opara; Andrea Remuzzi; Jeffrey Rogers; Justin M. Saul; Dror Seliktar; Keren Shapira-Schweitzer; Tom Smith; Daniel Solomon; Mark Van Dyke; James J. Yoo; Yuanyuan Zhang; Anthony Atala; Robert J. Stratta; Shay Soker

doi:10.1097/SLA.0b013e318243a4db

Regenerative medicine as applied to general surgery

Giuseppe Orlando, Kathryn J. Wood, Paolo De Coppi, Pedro M. Baptista, Kyle W. Binder, Khalil N. Bitar, Christopher Breuer, Luke Burnett, George Christ, Alan Farney, Marina Figliuzzi, James H. Holmes, Kenneth Koch, Paolo MacChiarini, Sayed Hadi Mirmalek Sani, Emmanuel Opara, Andrea Remuzzi, Jeffrey Rogers, Justin M. Saul, Dror SeliktarKeren Shapira-Schweitzer, Tom Smith, Daniel Solomon, Mark Van Dyke, James J. Yoo, Yuanyuan Zhang, Anthony Atala, Robert J. Stratta, Shay Soker

Surgery

Research output: Contribution to journal › Review article

79 Scopus citations

Abstract

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.

Original language	English (US)
Pages (from-to)	867-880
Number of pages	14
Journal	Annals of surgery
Volume	255
Issue number	5
DOIs	https://doi.org/10.1097/SLA.0b013e318243a4db
State	Published - May 1 2012

ASJC Scopus subject areas

Surgery

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Orlando, G., Wood, K. J., De Coppi, P., Baptista, P. M., Binder, K. W., Bitar, K. N., Breuer, C., Burnett, L., Christ, G., Farney, A., Figliuzzi, M., Holmes, J. H., Koch, K., MacChiarini, P., Sani, S. H. M., Opara, E., Remuzzi, A., Rogers, J., Saul, J. M., ... Soker, S. (2012). Regenerative medicine as applied to general surgery. Annals of surgery, 255(5), 867-880. https://doi.org/10.1097/SLA.0b013e318243a4db

Regenerative medicine as applied to general surgery. / Orlando, Giuseppe; Wood, Kathryn J.; De Coppi, Paolo; Baptista, Pedro M.; Binder, Kyle W.; Bitar, Khalil N.; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H.; Koch, Kenneth; MacChiarini, Paolo; Sani, Sayed Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M.; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J.; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J.; Soker, Shay.

In: Annals of surgery, Vol. 255, No. 5, 01.05.2012, p. 867-880.

Research output: Contribution to journal › Review article

Orlando, G, Wood, KJ, De Coppi, P, Baptista, PM, Binder, KW, Bitar, KN, Breuer, C, Burnett, L, Christ, G, Farney, A, Figliuzzi, M, Holmes, JH, Koch, K, MacChiarini, P, Sani, SHM, Opara, E, Remuzzi, A, Rogers, J, Saul, JM, Seliktar, D, Shapira-Schweitzer, K, Smith, T, Solomon, D, Van Dyke, M, Yoo, JJ, Zhang, Y, Atala, A, Stratta, RJ & Soker, S 2012, 'Regenerative medicine as applied to general surgery', Annals of surgery, vol. 255, no. 5, pp. 867-880. https://doi.org/10.1097/SLA.0b013e318243a4db

Orlando, Giuseppe ; Wood, Kathryn J. ; De Coppi, Paolo ; Baptista, Pedro M. ; Binder, Kyle W. ; Bitar, Khalil N. ; Breuer, Christopher ; Burnett, Luke ; Christ, George ; Farney, Alan ; Figliuzzi, Marina ; Holmes, James H. ; Koch, Kenneth ; MacChiarini, Paolo ; Sani, Sayed Hadi Mirmalek ; Opara, Emmanuel ; Remuzzi, Andrea ; Rogers, Jeffrey ; Saul, Justin M. ; Seliktar, Dror ; Shapira-Schweitzer, Keren ; Smith, Tom ; Solomon, Daniel ; Van Dyke, Mark ; Yoo, James J. ; Zhang, Yuanyuan ; Atala, Anthony ; Stratta, Robert J. ; Soker, Shay. / Regenerative medicine as applied to general surgery. In: Annals of surgery. 2012 ; Vol. 255, No. 5. pp. 867-880.

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