Abstract
Control of normal bladder function by the nervous system has been described in great detail. In some cases of injury to the spinal cord, neurogenic bladder dysfunction develops, typified by detrusor sphincter dyssynergia and decreasing bladder capacity and compliance. Numerous therapies, including anticholinergic agents, botulinum toxin, neuromodulation, and clean intermittent catheterization, have been used to maintain physiologic pressures in the neurogenic bladder. When bladder compliance falls to a dangerous level despite these treatments, enterocystoplasty has been the gold-standard therapy. Although this procedure increases bladder capacity and compliance, it has been plagued by complications, such as metabolic disorders, perforations, excessive mucous productions, and stones. Recently, the field of regenerative medicine has offered novel and improved therapies for this chronic condition. This review summarizes these recent advances.
| Original language | English |
|---|---|
| Pages (from-to) | 67-74 |
| Number of pages | 8 |
| Journal | Current Bladder Dysfunction Reports |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
Cite this
Regenerative medicine and the neurogenic bladder. / Hodges, Steve J.; Atala, Anthony.
In: Current Bladder Dysfunction Reports, Vol. 3, No. 2, 01.12.2008, p. 67-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regenerative medicine and the neurogenic bladder
AU - Hodges, Steve J.
AU - Atala, Anthony
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Control of normal bladder function by the nervous system has been described in great detail. In some cases of injury to the spinal cord, neurogenic bladder dysfunction develops, typified by detrusor sphincter dyssynergia and decreasing bladder capacity and compliance. Numerous therapies, including anticholinergic agents, botulinum toxin, neuromodulation, and clean intermittent catheterization, have been used to maintain physiologic pressures in the neurogenic bladder. When bladder compliance falls to a dangerous level despite these treatments, enterocystoplasty has been the gold-standard therapy. Although this procedure increases bladder capacity and compliance, it has been plagued by complications, such as metabolic disorders, perforations, excessive mucous productions, and stones. Recently, the field of regenerative medicine has offered novel and improved therapies for this chronic condition. This review summarizes these recent advances.
AB - Control of normal bladder function by the nervous system has been described in great detail. In some cases of injury to the spinal cord, neurogenic bladder dysfunction develops, typified by detrusor sphincter dyssynergia and decreasing bladder capacity and compliance. Numerous therapies, including anticholinergic agents, botulinum toxin, neuromodulation, and clean intermittent catheterization, have been used to maintain physiologic pressures in the neurogenic bladder. When bladder compliance falls to a dangerous level despite these treatments, enterocystoplasty has been the gold-standard therapy. Although this procedure increases bladder capacity and compliance, it has been plagued by complications, such as metabolic disorders, perforations, excessive mucous productions, and stones. Recently, the field of regenerative medicine has offered novel and improved therapies for this chronic condition. This review summarizes these recent advances.
UR - http://www.scopus.com/inward/record.url?scp=78349265081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78349265081&partnerID=8YFLogxK
U2 - 10.1007/s11884-008-0011-x
DO - 10.1007/s11884-008-0011-x
M3 - Article
AN - SCOPUS:78349265081
VL - 3
SP - 67
EP - 74
JO - Current Bladder Dysfunction Reports
JF - Current Bladder Dysfunction Reports
SN - 1931-7212
IS - 2
ER -