Regenerative medicine and organ transplantation: Past, present, and future

Giuseppe Orlando, Kathryn J. Wood, Robert J. Stratta, James J. Yoo, Anthony Atala, Shay Soker

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

This overview traces the history of regenerative medicine pertinent to organ transplantation, illustrates potential clinical applications reported to date, and highlights progress achieved in the field of complex modular organ engineering. Regenerative medicine can now produce relatively simple tissues such as skin, bladders, vessels, urethras, and upper airways, whereas engineering or generation of complex modular organs remains a major challenge. Ex vivo organ engineering may benefit from complementary investigations in the fields of developmental biology and stem cells and transplantation before its full potential can be realized.

Original languageEnglish
Pages (from-to)1310-1317
Number of pages8
JournalTransplantation
Volume91
Issue number12
DOIs
StatePublished - Jun 27 2011
Externally publishedYes

Keywords

  • Extracellular matrix
  • Regenerative medicine
  • Scaffold
  • Solid organ transplantation
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Transplantation

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