Regeneration of the neurosensory structures in the mammalian inner ear

Ph P. Lefebvre, B. Malgrange, Thomas R Van De Water, G. Moonen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Motivated by the absence of treatment of neurosensory deafness apt to restore auditory function or alter the course of progressive hearing loss, we developped two different experimental strategies to approach these diseases : one is otoprotection, designed to prevent further degradation of auditory function ; the other is regeneration which is defined as the replacement of hair cells in the deaf ear and their reconnection to the central nervous system through primary auditory neurons. In this paper, we summarize our data on the regeneration of auditory neurons and hair cells. Neuronal maintenance and regeneration was studied through an initial investigation of growth factors during inner development. Once the effect of various neurotrophic molecules was determined, the factors were tested on mature auditory neurons in vitro and in vivo. The hair cell regeneration was investigated on the basis of a concept derived from comparative physiology and from the study of the development of the inner ear. We showed that in young rats it is possible to induce the regeneration; repair of hair cells in the organ of Corti in cultures using retinoïc acid and transforming growth factor alpha. The clinical prospects of these findings of inner ear regeneration are discussed.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalActa Oto-Rhino-Laryngologica Belgica
Volume51
Issue number1
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

Inner Ear
Regeneration
Neurons
Auditory Hair Cells
Comparative Physiology
Organ of Corti
Transforming Growth Factor alpha
Deafness
Hearing Loss
Ear
Intercellular Signaling Peptides and Proteins
Central Nervous System
Maintenance
Acids

Keywords

  • Auditory neurons
  • Cochlea
  • Hair cell
  • Regeneration

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Lefebvre, P. P., Malgrange, B., Van De Water, T. R., & Moonen, G. (1997). Regeneration of the neurosensory structures in the mammalian inner ear. Acta Oto-Rhino-Laryngologica Belgica, 51(1), 1-10.

Regeneration of the neurosensory structures in the mammalian inner ear. / Lefebvre, Ph P.; Malgrange, B.; Van De Water, Thomas R; Moonen, G.

In: Acta Oto-Rhino-Laryngologica Belgica, Vol. 51, No. 1, 01.12.1997, p. 1-10.

Research output: Contribution to journalArticle

Lefebvre, PP, Malgrange, B, Van De Water, TR & Moonen, G 1997, 'Regeneration of the neurosensory structures in the mammalian inner ear', Acta Oto-Rhino-Laryngologica Belgica, vol. 51, no. 1, pp. 1-10.
Lefebvre PP, Malgrange B, Van De Water TR, Moonen G. Regeneration of the neurosensory structures in the mammalian inner ear. Acta Oto-Rhino-Laryngologica Belgica. 1997 Dec 1;51(1):1-10.
Lefebvre, Ph P. ; Malgrange, B. ; Van De Water, Thomas R ; Moonen, G. / Regeneration of the neurosensory structures in the mammalian inner ear. In: Acta Oto-Rhino-Laryngologica Belgica. 1997 ; Vol. 51, No. 1. pp. 1-10.
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