Regeneration of hemopoietic stroma in anemic mice of Sl/Sl(d) and W/W(v) genotypes

M. Tavassoli, R. J. Ratzan, A. Maniatis, W. H. Crosby

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The regeneration of hemopoietic stroma in anemic mice of genotypes Sl/Sl(d) and W/W(v) was studied by transplantation of spleen and bone marrow tissue to the subcutaneous tissue of their normal littermates. Both splenic and marrow implants from Sl/Sl(d) and W/W(v) mice showed normal regenerative patterns indicating that the regenerative potential of hemopoietic stroma is intact in both genotypes. The implants from Sl/Sl(d) mice into their normal littermates showed little erythropoietic activity, whereas the erythropoietic activity of implants from W/W(v) mice into their normal littermates was noticeably increased as compared to that of the donor organs. Since these implants represent a chimaeric structure with stroma of donor origin and hemopoietic cells from the host, this observation emphasizes the inability of the transplanted hemopoietic stroma from Sl/Sl(d) mice to support erythropoiesis in the presence of normal stem cells and microenvironment of their littermates, despite normal structural integrity of the transplanted stroma. These findings suggest a defective interaction between matrix and erythroid precursors in anemic Sl/Sl(d) mice.

Original languageEnglish (US)
Pages (from-to)518-526
Number of pages9
JournalRES Journal of the Reticuloendothelial Society
Volume13
Issue number6
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Hematology

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    Tavassoli, M., Ratzan, R. J., Maniatis, A., & Crosby, W. H. (1973). Regeneration of hemopoietic stroma in anemic mice of Sl/Sl(d) and W/W(v) genotypes. RES Journal of the Reticuloendothelial Society, 13(6), 518-526.