Regeneration of cone outer segments induced by CNTF

Rong Wen, Weng Tao, Lingyu Luo, Deqiang Huang, Konrad Kauper, Paul Stabila, Matthew M. LaVail, Alan M. Laties, Yiwen Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

Secondary cone degeneration in the transgenic rats carrying the S334ter rhodopsin mutation (S334ter-3 rats) starts at the peak of rod degeneration (PD12) and progresses with age. An early sign of cone degeneration is the loss of cone outer segments (COS) distributed in many small patches throughout the retina. Cone cell death occurs about 2 months later. When treated with CNTF (ciliary neurotrophic factor), impaired cones regenerate COS. Sustained delivery of CNTF prevents cones from degeneration and helps to maintain COS and function. These results indicate that cone degeneration is reversible at early stages and support a therapeutic strategy of sustained delivery of CNTF to prevent cone degeneration.

Original languageEnglish (US)
Title of host publicationRetinal Degenerative Diseases
EditorsMatthew LaVail, Robert Anderson, Christian Grimm, John Ash, Joe Hollyfield
Pages93-99
Number of pages7
DOIs
StatePublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume723
ISSN (Print)0065-2598

Keywords

  • CNTF
  • Cone
  • Cone ERG
  • Cone Outer Segments
  • Neuroprotection
  • PNA
  • Regeneration
  • Retinal Degeneration
  • S334ter Rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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