TY - JOUR
T1 - Regeneration and plasticity of neuronal connections in the leech
AU - Mason, Adrian
AU - Muller, Kenneth J.
N1 - Funding Information:
are also similar to varicositiesse enclus-longedd istals tumps urvivailn vertebrates, 22 Jansen,J K.S., Muller, l~. J and Nicholts. teredw ithinthe connectiveasf tera nerve including mammals, suggests that J. G. (1974)JP. hvsioL(L ondon2) 42,289--3(15 cord lesion~",aLH owever, no chemical involvemenotf distal stumpsin regenera-23 JansenJ., K. S. andN ichollsJ, G {t972P)r ~,~ synapsems adeb y isolateds tumphs avey et tion may not be confinetdo invertebrates. 24 KrasneF,. B andL ee.S .-H f ]o77)Sctct~c!'¢~. 8 NadA cad.S ci.U .S.A.6 9,b 3~-~339 beens eenin thel eech( cf. Ref. 24). Growth 517-519 by severeda xons tumpcso uldc onceivably Acknowledgements 25 Kristan, WB . play a role in the regeneratioonf connec-We thank Ellen Elliott aJonhdn H edreenfo r 215-220 tions by making it more likely that the useful commentosn the manuscripTt.h e 26 KristanW, . B, Jr andG uthrieP, . B. 11977) stumpsw ould be locatedb y regenerating authors' work is supported ibny p aa NrtA TO 27 KuffierS, . W, andN ichollsJ, G. (!976) From BrainR es.1 31,191-195 axons. Fellowship to Adrian Mason and USPHS grant Neuro¢t~o Brain,S inaueMr, assachusetts NS-15014 and a McKnight Foundation Neuro- Conclusions (London)2 966, 55-657 science Development Award. 28 Mason,A . and Muller,K . J (1982)N ature
PY - 1983
Y1 - 1983
N2 - Although most studies have analysed regeneration at the cell-population level, in many species, including mammals, individual neurons can regenerate selective connections. In order to examine the specificity of regeneration at the level of connections between single neurons attention has turned to invertebrates with their simpler, experimentally more accessible nervous systems. The medicinal leech, once an indispensable part of the medical armoury, possesses a nervous system which has proved particularly useful for studies on recovery from nerve injury. Not only can individual regenerating neurons and their targets be identified in this animal, but it is also possible to manipulate various cellular elements of the system and directly test what stimulates axons to grow and regenerate connections.
AB - Although most studies have analysed regeneration at the cell-population level, in many species, including mammals, individual neurons can regenerate selective connections. In order to examine the specificity of regeneration at the level of connections between single neurons attention has turned to invertebrates with their simpler, experimentally more accessible nervous systems. The medicinal leech, once an indispensable part of the medical armoury, possesses a nervous system which has proved particularly useful for studies on recovery from nerve injury. Not only can individual regenerating neurons and their targets be identified in this animal, but it is also possible to manipulate various cellular elements of the system and directly test what stimulates axons to grow and regenerate connections.
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U2 - 10.1016/0166-2236(83)90080-2
DO - 10.1016/0166-2236(83)90080-2
M3 - Review article
AN - SCOPUS:0020641713
VL - 6
SP - 172
EP - 176
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - C
ER -