Reflections on Bruce S. McEwen’s contributions to stress neurobiology and so much more

Firdaus S. Dhabhar, Michael J. Meaney, Robert M. Sapolsky, Robert L. Spencer

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The authors highlight, from a firsthand perspective, Bruce S. McEwen's seminal influence on the field of stress neurobiology and beyond, and how these investigations have yielded important insights, principles and critical questions that continue to guide stress research today. Featured are discussion of: 1) the important inverted-U relationship between stress/glucocorticoids and optimal physiological function, 2) stress adaptation and the role of adaptive stress responses, 3) mechanisms by which the short-term stress response promotes heightened immune function and immunity, and 4) the far reaching impact of the theoretical framework of allostasis and allostatic load—concepts that have created new bridges between stress physiology, biomedical sciences, health psychology and sociology.

Original languageEnglish (US)
Pages (from-to)499-508
Number of pages10
JournalStress
Volume23
Issue number5
DOIs
StatePublished - Sep 2 2020

Keywords

  • Glucocorticoids
  • HPA axis
  • allostasis
  • allostatic load
  • glucocorticoid receptor
  • mineralocorticoid receptor
  • psychoneuroimmunology
  • stress adaptation

ASJC Scopus subject areas

  • Physiology
  • Neuropsychology and Physiological Psychology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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