Reflectance Confocal Microscopy in the Daily Practice

Verena Ahlgrimm-Siess, Rainer Hofmann-Wellenhof, Theresa Cao, Margaret Oliviero, Alon Scope, Harold S. Rabinovitz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Reflectance confocal microscopy (RCM) allows noninvasive imaging of the epidermis and superficial dermis. Like dermoscopy, RCM acquires images in the horizontal plane (en face), allowing assessment of tissue pathology underlying dermoscopic structures of interest at a cellular-level resolution. Thus, clinicians using dermoscopy may find RCM to be particularly useful. Our aim was to show the value of RCM for diagnosis and management decisions related to pigmented and nonpigmented skin neoplasms seen in daily practice. Six cases of clinically and dermoscopically equivocal skin lesions, for which RCM facilitated making the correct diagnosis, are presented. Final diagnoses were made based on histopathologic analysis. Three flat pigmented skin lesions with dermoscopic signs of regression showed distinct RCM features that allowed their correct classification as pigmented basal cell carcinoma, pigmented actinic keratosis, and melanoma on sun-damaged skin. A flat nonpigmented skin lesion on the face, which did not show distinct clinical or dermoscopic features, was correctly diagnosed as basal cell carcinoma based on RCM findings. In addition, the response of a pigmented actinic keratosis and a melanoma in situ on sun-damaged skin to noninvasive topical treatment was monitored using RCM. RCM is a promising and practical imaging tool for the diagnosis and follow-up of pigmented and nonpigmented skin lesions.

Original languageEnglish (US)
Pages (from-to)180-189
Number of pages10
JournalSeminars in Cutaneous Medicine and Surgery
Volume28
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Confocal Microscopy
Skin
Dermoscopy
Actinic Keratosis
Basal Cell Carcinoma
Solar System
Melanoma
Skin Neoplasms
Dermis
Epidermis
Pathology

Keywords

  • dermoscopy
  • melanoma
  • nonmelanocytic skin tumors
  • reflectance confocal microscopy

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Ahlgrimm-Siess, V., Hofmann-Wellenhof, R., Cao, T., Oliviero, M., Scope, A., & Rabinovitz, H. S. (2009). Reflectance Confocal Microscopy in the Daily Practice. Seminars in Cutaneous Medicine and Surgery, 28(3), 180-189. https://doi.org/10.1016/j.sder.2009.06.008

Reflectance Confocal Microscopy in the Daily Practice. / Ahlgrimm-Siess, Verena; Hofmann-Wellenhof, Rainer; Cao, Theresa; Oliviero, Margaret; Scope, Alon; Rabinovitz, Harold S.

In: Seminars in Cutaneous Medicine and Surgery, Vol. 28, No. 3, 09.2009, p. 180-189.

Research output: Contribution to journalArticle

Ahlgrimm-Siess, V, Hofmann-Wellenhof, R, Cao, T, Oliviero, M, Scope, A & Rabinovitz, HS 2009, 'Reflectance Confocal Microscopy in the Daily Practice', Seminars in Cutaneous Medicine and Surgery, vol. 28, no. 3, pp. 180-189. https://doi.org/10.1016/j.sder.2009.06.008
Ahlgrimm-Siess V, Hofmann-Wellenhof R, Cao T, Oliviero M, Scope A, Rabinovitz HS. Reflectance Confocal Microscopy in the Daily Practice. Seminars in Cutaneous Medicine and Surgery. 2009 Sep;28(3):180-189. https://doi.org/10.1016/j.sder.2009.06.008
Ahlgrimm-Siess, Verena ; Hofmann-Wellenhof, Rainer ; Cao, Theresa ; Oliviero, Margaret ; Scope, Alon ; Rabinovitz, Harold S. / Reflectance Confocal Microscopy in the Daily Practice. In: Seminars in Cutaneous Medicine and Surgery. 2009 ; Vol. 28, No. 3. pp. 180-189.
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