Reference intervals for acute phase protein and serum protein electrophoresis values in captive Asian elephants (Elephas maximus)

Ramiro Isaza, Ellen Wiedner, Sarah Hiser, Carolyn Cray

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Acute phase protein (APP) immunoassays and serum protein electrophoresis (SPEP) are assays for evaluating the inflammatory response and have use as diagnostic tools in a variety of species. Acute phase proteins are markers of inflammation that are highly conserved across different species while SPEP separates and quantifies serum protein fractions based on their physical properties. In the current study, serum samples from 35 clinically healthy Asian elephants (Elephas maximus) were analyzed using automated assays for C-reactive protein, serum amyloid A, and haptoglobin and SPEP. Robust methods were used to generate reference intervals for the APPs: C-reactive protein (1.3–12.8 mg/l), serum amyloid A (0–47.5 mg/l), and haptoglobin (0–1.10 mg/ml). In addition, SPEP was performed on these samples to establish reference intervals for each protein fraction. A combination of APPs and SPEP measurements are valuable adjunctive diagnostic tools in elephant health care.

Original languageEnglish (US)
Pages (from-to)616-621
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2014

Keywords

  • Acute phase protein
  • acute phase response
  • Asian elephants
  • Elephas maximus
  • serum amyloid A
  • serum protein electrophoresis

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