Reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by [D-Trp6]-Luteinizing Hormone Releasing Hormone in hypophysectomized rats

A. Arimura, P. Serafini, S. Talbot, A. V. Schally

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Adult and immature male rats were hypophysectomized and injected daily with saline or 0.2 or 2 μg of superactive Luteinizing Hormone Releasing Hormone (LHRH) agonist, [D-Trp6]-LHRH subcutaneously for seven days - with, or without, concomitant treatment of 1 IU Human Chorionic Gonadotropin (hCG) or 50 IU Pregnant Mare Serum. The administration of [D-Trp6]-LHRH reduced Luteinizing Hormone/Human Chorionic Gonadotropin receptors in all cases. The magnitude of this reduction was dose-related. As small a dose as 0.2 μg of the peptide resulted in approximately a 72% reduction of the receptors. The results suggest a direct action of [D-Trp6]-LHRH on the testis. It also indicated that reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by the peptide is not necessarily due to the over-stimulation of Luteinizing Hormone (LH) release from the pituitary through a "down regulation" mechanism.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalBiochemical and biophysical research communications
Volume90
Issue number3
DOIs
StatePublished - Oct 12 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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