Abstract
Adult and immature male rats were hypophysectomized and injected daily with saline or 0.2 or 2 μg of superactive Luteinizing Hormone Releasing Hormone (LHRH) agonist, [D-Trp6]-LHRH subcutaneously for seven days - with, or without, concomitant treatment of 1 IU Human Chorionic Gonadotropin (hCG) or 50 IU Pregnant Mare Serum. The administration of [D-Trp6]-LHRH reduced Luteinizing Hormone/Human Chorionic Gonadotropin receptors in all cases. The magnitude of this reduction was dose-related. As small a dose as 0.2 μg of the peptide resulted in approximately a 72% reduction of the receptors. The results suggest a direct action of [D-Trp6]-LHRH on the testis. It also indicated that reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by the peptide is not necessarily due to the over-stimulation of Luteinizing Hormone (LH) release from the pituitary through a "down regulation" mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 687-693 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 90 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 12 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by [D-Trp6]-Luteinizing Hormone Releasing Hormone in hypophysectomized rats. / Arimura, A.; Serafini, P.; Talbot, S.; Schally, Andrew V.
In: Biochemical and Biophysical Research Communications, Vol. 90, No. 3, 12.10.1979, p. 687-693.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by [D-Trp6]-Luteinizing Hormone Releasing Hormone in hypophysectomized rats
AU - Arimura, A.
AU - Serafini, P.
AU - Talbot, S.
AU - Schally, Andrew V
PY - 1979/10/12
Y1 - 1979/10/12
N2 - Adult and immature male rats were hypophysectomized and injected daily with saline or 0.2 or 2 μg of superactive Luteinizing Hormone Releasing Hormone (LHRH) agonist, [D-Trp6]-LHRH subcutaneously for seven days - with, or without, concomitant treatment of 1 IU Human Chorionic Gonadotropin (hCG) or 50 IU Pregnant Mare Serum. The administration of [D-Trp6]-LHRH reduced Luteinizing Hormone/Human Chorionic Gonadotropin receptors in all cases. The magnitude of this reduction was dose-related. As small a dose as 0.2 μg of the peptide resulted in approximately a 72% reduction of the receptors. The results suggest a direct action of [D-Trp6]-LHRH on the testis. It also indicated that reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by the peptide is not necessarily due to the over-stimulation of Luteinizing Hormone (LH) release from the pituitary through a "down regulation" mechanism.
AB - Adult and immature male rats were hypophysectomized and injected daily with saline or 0.2 or 2 μg of superactive Luteinizing Hormone Releasing Hormone (LHRH) agonist, [D-Trp6]-LHRH subcutaneously for seven days - with, or without, concomitant treatment of 1 IU Human Chorionic Gonadotropin (hCG) or 50 IU Pregnant Mare Serum. The administration of [D-Trp6]-LHRH reduced Luteinizing Hormone/Human Chorionic Gonadotropin receptors in all cases. The magnitude of this reduction was dose-related. As small a dose as 0.2 μg of the peptide resulted in approximately a 72% reduction of the receptors. The results suggest a direct action of [D-Trp6]-LHRH on the testis. It also indicated that reduction of testicular Luteinizing Hormone/Human Chorionic Gonadotropin receptors by the peptide is not necessarily due to the over-stimulation of Luteinizing Hormone (LH) release from the pituitary through a "down regulation" mechanism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018643942&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(79)91882-5
DO - 10.1016/0006-291X(79)91882-5
M3 - Article
C2 - 228668
AN - SCOPUS:0018643942
VL - 90
SP - 687
EP - 693
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -