Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by emblica officinalis gaertn

K. R. Anilakumar, Nagaraj Nagathihalli, K. Santhanam

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effect of prefeeding of dehydrated E. officinalis (amla) powder at 5 and 10% levels on hexachlorocyclohexane (HCH)-induced changes in multicomponent antioxidant system and lipid peroxides in rat liver was studied. HCH induced significant elevation in hepatic malondialdehyde, conjugated dienes and hydroperoxides. The prefeeding of amla at 10% level could decrease the formation of these lipid peroxides significantly. The HCH abuse resulted in a significant reduction in hepatic glutathione S-transferase (GST), glucose-6-phosphate dehydrogenase (G-6-PDH) and superoxide dismutase (SOD) activities with an elevation in the activities of glutathione peroxidase and γ -glutamyl transpeptidase (GGT). On the other hand, the HCH-induced impairment in hepatic catalase, G-6-PDH and SOD activities were modulated by amla at the 10% level of intake. Prefeeding of amla at 5 and 10% levels appeared to reduce the HCH-induced raise in renal GGT activity. The results show the elevation of hepatic antioxidant system and reduction of cytotoxic products as a result of prefeeding of amla, which were otherwise affected by the HCH administration.

Original languageEnglish (US)
Pages (from-to)450-454
Number of pages5
JournalIndian Journal of Experimental Biology
Volume45
Issue number5
StatePublished - May 2007
Externally publishedYes

Fingerprint

Phyllanthus emblica
Lindane
Oxidative stress
Cytotoxicity
Liver
Rats
Oxidative Stress
Antioxidants
Glucose
Phosphates
gamma-Glutamyltransferase
Glucosephosphate Dehydrogenase
Lipid Peroxides
Glutathione Peroxidase
Superoxide Dismutase
Powders
Glutathione Transferase
Malondialdehyde
Catalase
Hydrogen Peroxide

Keywords

  • Amla
  • Antioxidant enzymes
  • Hexachlorocyclohexane
  • Lipid peroxides
  • Oxidative stress
  • Rat liver

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology
  • Bioengineering

Cite this

Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by emblica officinalis gaertn. / Anilakumar, K. R.; Nagathihalli, Nagaraj; Santhanam, K.

In: Indian Journal of Experimental Biology, Vol. 45, No. 5, 05.2007, p. 450-454.

Research output: Contribution to journalArticle

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