Reduction of electrical coupling between Necturus taste receptor cells, a possible role in acid taste

Albertino Bigiani; Stephen D. Roper

doi:10.1016/0304-3940(94)90085-X

Reduction of electrical coupling between Necturus taste receptor cells, a possible role in acid taste

Albertino Bigiani, Stephen D. Roper

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patch clamp technique to a slice preparation of Necturus lingual epithelium, we found that electrical coupling between taste receptor cells was strongly reduced by cytoplasmic acidification. Therefore, electrical coupling in taste buds might be modified during acid stimulation.

Original language	English (US)
Pages (from-to)	212-216
Number of pages	5
Journal	Neuroscience Letters
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90085-X
State	Published - Aug 1 1994
Externally published	Yes

Keywords

Acid transduction
Electrical coupling
Gustation
Intracellular pH
Necturus
Patch-clamp
Taste bud

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90085-X

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title = "Reduction of electrical coupling between Necturus taste receptor cells, a possible role in acid taste",

abstract = "Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patch clamp technique to a slice preparation of Necturus lingual epithelium, we found that electrical coupling between taste receptor cells was strongly reduced by cytoplasmic acidification. Therefore, electrical coupling in taste buds might be modified during acid stimulation.",

keywords = "Acid transduction, Electrical coupling, Gustation, Intracellular pH, Necturus, Patch-clamp, Taste bud",

author = "Albertino Bigiani and Roper, {Stephen D.}",

note = "Funding Information: We thank Drs. R. Dehty,D . Ewald, and S. Kinnamon for criticald iscussionsT.h is studyw as supportedin part by NIH Grants DC00374,A G06557,a nd DC00244.",

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AU - Bigiani, Albertino

AU - Roper, Stephen D.

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N2 - Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patch clamp technique to a slice preparation of Necturus lingual epithelium, we found that electrical coupling between taste receptor cells was strongly reduced by cytoplasmic acidification. Therefore, electrical coupling in taste buds might be modified during acid stimulation.

AB - Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patch clamp technique to a slice preparation of Necturus lingual epithelium, we found that electrical coupling between taste receptor cells was strongly reduced by cytoplasmic acidification. Therefore, electrical coupling in taste buds might be modified during acid stimulation.

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KW - Electrical coupling

KW - Gustation

KW - Intracellular pH

KW - Necturus

KW - Patch-clamp

KW - Taste bud

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Reduction of electrical coupling between Necturus taste receptor cells, a possible role in acid taste

Abstract

Keywords

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