Reduction of CD4 + T cells in vivo does not affect virus load in macaque elite controllers

Philip A. Mudd, Adam J. Ericsen, Andrew A. Price, Nancy A. Wilson, Keith A. Reimann, David I. Watkins

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A small percentage of human immunodeficiency virus (HIV)- and simian immunodeficiency virus (SIV)-infected individuals spontaneously control virus replication. The majority of these elite controllers mount high-frequency virus-specific CD4 + T cell responses. To evaluate the role these responses might play in viral control, we depleted two elite controller macaques of CD4 + cells. SIV-specific CD4 + T cell responses did not return to baseline levels until 8 weeks postdepletion. Viral loads remained stable throughout the experiment, suggesting that SIV-specific CD4 + T cell responses may not play a direct role in controlling chronic viral replication in these elite controllers.

Original languageEnglish (US)
Pages (from-to)7454-7459
Number of pages6
JournalJournal of virology
Issue number14
StatePublished - Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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