Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery

Yukiko Ueda, Tahar Hajri, Dunfa Peng, Pamela A. Marks-Shulman, Robyn A. Tamboli, Bassam Shukrallah, Jabbar Saliba, Kareem Jabbour, Wael El-Rifai, Nada A. Abumrad, Naji N. Abumrad

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Obesity is associated with increased markers of oxidative stress. We examined whether oxidative stress is reduced within the first week after Roux-en-Y gastric bypass (RYGB) surgery and could be related to changes in adipose tissue depots. The reactive oxygen species (ROS) marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and activity of antioxidant glutathione peroxidases (GPX) in plasma were compared before and ∼1 week after RYGB. The effects of RYGB on subcutaneous adipose tissue and interstitial fluid 8-iso-PGF2α levels and subcutaneous adipose tissue expression of GPX-3 were also assessed. Levels of 8-iso-PGF2α in subcutaneous and visceral adipose tissue were determined. Plasma 8-iso-PGF2α levels decreased (122±75 to 56 15pg/ml, P = 0.001) and GPX activity increased (84±18 to 108 25nmol/min/ml, P = 0.003) in the first week post-RYGB. RYGB also resulted in reductions of 8-iso-PGF2α in subcutaneous adipose tissue (1,742 931 to 1,132 420pg/g fat, P = 0.046) and interstitial fluid (348±118 to 221±83pg/ml, P = 0.046) that were comparable to plasma (26-33%, P = 0.74). Adipose GPX-3 expression was increased (6.7 4.7-fold, P = 0.004) in the first postoperative week. The improvements in oxidative stress occurred with minimal weight loss (2.4±3.4%, P = 0.031) and elevations in plasma interleukin-6 (18.0 46.8 to 28.0 58.9pg/ml, P = 0.004). Subcutaneous and visceral adipose tissues express comparable 8-iso-PGF2α levels (1,204 470 and 1,331 264pg/g fat, respectively; P = 0.34). These data suggest that RYGB affects adipose tissue leading to the restoration of adipose redox balance within the first postoperative week and that plasma 8-iso-PGF2α is primarily derived from subcutaneous adipose tissue.

Original languageEnglish (US)
Pages (from-to)1663-1668
Number of pages6
JournalObesity
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Fingerprint

Dinoprost
Gastric Bypass
Subcutaneous Fat
Glutathione Peroxidase
Oxidative Stress
Intra-Abdominal Fat
Extracellular Fluid
Adipose Tissue
Fats
Oxidation-Reduction
Weight Loss
Interleukin-6
Reactive Oxygen Species
Obesity
Antioxidants

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Ueda, Y., Hajri, T., Peng, D., Marks-Shulman, P. A., Tamboli, R. A., Shukrallah, B., ... Abumrad, N. N. (2011). Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery. Obesity, 19(8), 1663-1668. https://doi.org/10.1038/oby.2011.58

Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery. / Ueda, Yukiko; Hajri, Tahar; Peng, Dunfa; Marks-Shulman, Pamela A.; Tamboli, Robyn A.; Shukrallah, Bassam; Saliba, Jabbar; Jabbour, Kareem; El-Rifai, Wael; Abumrad, Nada A.; Abumrad, Naji N.

In: Obesity, Vol. 19, No. 8, 01.08.2011, p. 1663-1668.

Research output: Contribution to journalArticle

Ueda, Y, Hajri, T, Peng, D, Marks-Shulman, PA, Tamboli, RA, Shukrallah, B, Saliba, J, Jabbour, K, El-Rifai, W, Abumrad, NA & Abumrad, NN 2011, 'Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery', Obesity, vol. 19, no. 8, pp. 1663-1668. https://doi.org/10.1038/oby.2011.58
Ueda Y, Hajri T, Peng D, Marks-Shulman PA, Tamboli RA, Shukrallah B et al. Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery. Obesity. 2011 Aug 1;19(8):1663-1668. https://doi.org/10.1038/oby.2011.58
Ueda, Yukiko ; Hajri, Tahar ; Peng, Dunfa ; Marks-Shulman, Pamela A. ; Tamboli, Robyn A. ; Shukrallah, Bassam ; Saliba, Jabbar ; Jabbour, Kareem ; El-Rifai, Wael ; Abumrad, Nada A. ; Abumrad, Naji N. / Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery. In: Obesity. 2011 ; Vol. 19, No. 8. pp. 1663-1668.
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