Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy

Surendra J. Chavan, Seetha L. Tamma, Mark Kaplan, Merril Gersten, Savita G Pahwa

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Patients with HIV infection manifest increased T lymphocyte apoptosis. This study investigated the influence of antiretroviral therapy (ART) upon lymphocyte apoptosis in 23 HIV-infected adults naive to protease inhibitors. Patients were enrolled in a treatment trial consisting of Nelfinavir (NFV), d4T, or NFV + d4T for 24 weeks, followed by triple therapy (NFV + reverse transcriptase inhibitors) for an additional 24 weeks. Spontaneous T cell apoptosis in cultured PBMC decreased by 23.67 ± 18.2% (P < 0.006) at 48 weeks and plasma HIV RNA decreased by 1.79 ± 0.59 log10 RNA copies/ml (P < 0.001). The absolute decrease and slope of T cell apoptosis correlated with plasma virus load and with activated CD8 T cells and was inversely correlated with CD4 T cells. We conclude that reduction in chronic antigenic stimulation and the absence of cellular signals elicited by viral products contribute to the rescue of T lymphocytes from apoptosis, which facilitates immunologic recovery in ART-treated patients.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalClinical Immunology
Volume93
Issue number1
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

Fingerprint

HIV
Nelfinavir
Apoptosis
T-Lymphocytes
Therapeutics
RNA
Reverse Transcriptase Inhibitors
Protease Inhibitors
HIV Infections
Lymphocytes
Viruses

Keywords

  • Apoptosis
  • FACS
  • HIV/AIDS
  • Human
  • T-lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy. / Chavan, Surendra J.; Tamma, Seetha L.; Kaplan, Mark; Gersten, Merril; Pahwa, Savita G.

In: Clinical Immunology, Vol. 93, No. 1, 01.10.1999, p. 24-33.

Research output: Contribution to journalArticle

Chavan, Surendra J. ; Tamma, Seetha L. ; Kaplan, Mark ; Gersten, Merril ; Pahwa, Savita G. / Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy. In: Clinical Immunology. 1999 ; Vol. 93, No. 1. pp. 24-33.
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