Reducing apoptosis of porcine cartilage through mechanical loading following impact injury

Andre A. Abadin, Lauren L. Vernon, Lee D. Kaplan, Chun Yuh C. Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Acute cartilage injury can induce apoptosis, which can lead to osteoarthritis later on in life. Mechanical loading has been shown to halt IL-1 induced cartilage degradation. This study investigated the effect of mechanical loading on chondrocyte apoptosis following a mechanical injury. We analyzed 8 mm cartilage plugs harvested from the trochlea region of 3 porcine knees. We impacted the cartilage plugs using a drop tower to induce an injury response. Twentyfour hours after impaction the cells were analyzed for total number of chondrocytes, chondrocyte viability, and histology, which included apoptotic TUNEL staining. These results indicate that mechanical loading has a beneficial effect on injured cartilage and may be used as an early intervention to preserve cell viability.

Original languageEnglish (US)
Title of host publicationProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages149-150
Number of pages2
DOIs
StatePublished - Aug 5 2013
Event29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States
Duration: May 3 2013May 5 2013

Publication series

NameProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013

Other

Other29th Southern Biomedical Engineering Conference, SBEC 2013
CountryUnited States
CityMiami, FL
Period5/3/135/5/13

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Abadin, A. A., Vernon, L. L., Kaplan, L. D., & Huang, C. Y. C. (2013). Reducing apoptosis of porcine cartilage through mechanical loading following impact injury. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 149-150). [6525720] (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013). https://doi.org/10.1109/SBEC.2013.83