Reduced Tear Meniscus Dynamics in Dry Eye Patients With Aqueous Tear Deficiency

Yimin Yuan, Jianhua Wang, Qi Chen, Aizhu Tao, Meixiao Shen, Mohamed Abou Shousha

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: To measure the tear meniscus dynamics in aqueous tear deficiency dry eye patients using optical coherence tomography. Design: Clinical research study of a laboratory technique. Methods: Twenty-five aqueous tear deficiency dry eye patients and 30 healthy subjects were recruited. Upper and lower tear menisci of 1 randomly selected eye of each participant were imaged during normal and delayed blinking using optical coherence tomography. Measured parameters included upper tear meniscus height and volume, lower tear meniscus height and volume, the blink outcome defined as the meniscus volume change during blink action, and open eye outcome defined as the meniscus volume change during the open eye period. Results: During normal blinking, both tear meniscus height and volume before blink in dry eye patients were significantly smaller than those in healthy subjects, except for the upper tear meniscus volume. During normal blinking, the blink outcome and open eye outcome of lower tear meniscus were significantly smaller in dry eye patients compared with healthy subjects. During delayed blinking, the upper and lower tear menisci heights and volumes significantly increased in both groups. However, dry eye patients had smaller increases than healthy subjects. During delayed blinking, the open eye outcomes of upper and lower tear menisci were smaller in dry eye patients than healthy subjects. Conclusions: Dry eye patients seem to have reduced tear meniscus dynamics during normal blinking and smaller increases of meniscus volume during delayed blinking. Analysis of tear meniscus dynamics may provide more insight in the altered tear system in dry eye patients.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume149
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Tears
Blinking
Healthy Volunteers
Optical Coherence Tomography
Meniscus
Research Design

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Reduced Tear Meniscus Dynamics in Dry Eye Patients With Aqueous Tear Deficiency. / Yuan, Yimin; Wang, Jianhua; Chen, Qi; Tao, Aizhu; Shen, Meixiao; Abou Shousha, Mohamed.

In: American Journal of Ophthalmology, Vol. 149, No. 6, 01.06.2010.

Research output: Contribution to journalArticle

@article{10961a80103a45acb6f0fc009d2874ae,
title = "Reduced Tear Meniscus Dynamics in Dry Eye Patients With Aqueous Tear Deficiency",
abstract = "Purpose: To measure the tear meniscus dynamics in aqueous tear deficiency dry eye patients using optical coherence tomography. Design: Clinical research study of a laboratory technique. Methods: Twenty-five aqueous tear deficiency dry eye patients and 30 healthy subjects were recruited. Upper and lower tear menisci of 1 randomly selected eye of each participant were imaged during normal and delayed blinking using optical coherence tomography. Measured parameters included upper tear meniscus height and volume, lower tear meniscus height and volume, the blink outcome defined as the meniscus volume change during blink action, and open eye outcome defined as the meniscus volume change during the open eye period. Results: During normal blinking, both tear meniscus height and volume before blink in dry eye patients were significantly smaller than those in healthy subjects, except for the upper tear meniscus volume. During normal blinking, the blink outcome and open eye outcome of lower tear meniscus were significantly smaller in dry eye patients compared with healthy subjects. During delayed blinking, the upper and lower tear menisci heights and volumes significantly increased in both groups. However, dry eye patients had smaller increases than healthy subjects. During delayed blinking, the open eye outcomes of upper and lower tear menisci were smaller in dry eye patients than healthy subjects. Conclusions: Dry eye patients seem to have reduced tear meniscus dynamics during normal blinking and smaller increases of meniscus volume during delayed blinking. Analysis of tear meniscus dynamics may provide more insight in the altered tear system in dry eye patients.",
author = "Yimin Yuan and Jianhua Wang and Qi Chen and Aizhu Tao and Meixiao Shen and {Abou Shousha}, Mohamed",
year = "2010",
month = "6",
day = "1",
doi = "10.1016/j.ajo.2010.01.004",
language = "English",
volume = "149",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Reduced Tear Meniscus Dynamics in Dry Eye Patients With Aqueous Tear Deficiency

AU - Yuan, Yimin

AU - Wang, Jianhua

AU - Chen, Qi

AU - Tao, Aizhu

AU - Shen, Meixiao

AU - Abou Shousha, Mohamed

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Purpose: To measure the tear meniscus dynamics in aqueous tear deficiency dry eye patients using optical coherence tomography. Design: Clinical research study of a laboratory technique. Methods: Twenty-five aqueous tear deficiency dry eye patients and 30 healthy subjects were recruited. Upper and lower tear menisci of 1 randomly selected eye of each participant were imaged during normal and delayed blinking using optical coherence tomography. Measured parameters included upper tear meniscus height and volume, lower tear meniscus height and volume, the blink outcome defined as the meniscus volume change during blink action, and open eye outcome defined as the meniscus volume change during the open eye period. Results: During normal blinking, both tear meniscus height and volume before blink in dry eye patients were significantly smaller than those in healthy subjects, except for the upper tear meniscus volume. During normal blinking, the blink outcome and open eye outcome of lower tear meniscus were significantly smaller in dry eye patients compared with healthy subjects. During delayed blinking, the upper and lower tear menisci heights and volumes significantly increased in both groups. However, dry eye patients had smaller increases than healthy subjects. During delayed blinking, the open eye outcomes of upper and lower tear menisci were smaller in dry eye patients than healthy subjects. Conclusions: Dry eye patients seem to have reduced tear meniscus dynamics during normal blinking and smaller increases of meniscus volume during delayed blinking. Analysis of tear meniscus dynamics may provide more insight in the altered tear system in dry eye patients.

AB - Purpose: To measure the tear meniscus dynamics in aqueous tear deficiency dry eye patients using optical coherence tomography. Design: Clinical research study of a laboratory technique. Methods: Twenty-five aqueous tear deficiency dry eye patients and 30 healthy subjects were recruited. Upper and lower tear menisci of 1 randomly selected eye of each participant were imaged during normal and delayed blinking using optical coherence tomography. Measured parameters included upper tear meniscus height and volume, lower tear meniscus height and volume, the blink outcome defined as the meniscus volume change during blink action, and open eye outcome defined as the meniscus volume change during the open eye period. Results: During normal blinking, both tear meniscus height and volume before blink in dry eye patients were significantly smaller than those in healthy subjects, except for the upper tear meniscus volume. During normal blinking, the blink outcome and open eye outcome of lower tear meniscus were significantly smaller in dry eye patients compared with healthy subjects. During delayed blinking, the upper and lower tear menisci heights and volumes significantly increased in both groups. However, dry eye patients had smaller increases than healthy subjects. During delayed blinking, the open eye outcomes of upper and lower tear menisci were smaller in dry eye patients than healthy subjects. Conclusions: Dry eye patients seem to have reduced tear meniscus dynamics during normal blinking and smaller increases of meniscus volume during delayed blinking. Analysis of tear meniscus dynamics may provide more insight in the altered tear system in dry eye patients.

UR - http://www.scopus.com/inward/record.url?scp=77952544425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952544425&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2010.01.004

DO - 10.1016/j.ajo.2010.01.004

M3 - Article

C2 - 20378096

AN - SCOPUS:77952544425

VL - 149

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 6

ER -