Reduced serum ceruloplasmin levels in hereditary haemochromatosis

Gaetano Cairo, Dario Conte, Laura Bianchi, Mirella Fraquelli, Stefania Recalcati

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

As ceruloplasmin (Cp) seems to be involved in iron mobilization, serum Cp levels were measured in 35 patients with hereditary haemochromatosis (HH), 12 with acquired iron overload (AIO) and 36 healthy subjects. Cp was lower in HH patients than in controls (P < 0.001); no difference was found between untreated HH patients and those on a phlebotomy programme (P = 0.07) and between the HH patients carrying the normal and the mutated alleles of the HFE gene (P = 0.8). Cp levels in AIO subjects were significantly higher than in HH patients (P < 0.004) and similar to those of controls (P = 0.2). No differences in albumin, α1 acid glycoprotein and copper serum levels were observed in the three groups.

Original languageEnglish (US)
Pages (from-to)226-229
Number of pages4
JournalBritish Journal of Haematology
Volume114
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Ceruloplasmin
  • Copper
  • Ferroxidase
  • Haemochromatosis
  • Iron

ASJC Scopus subject areas

  • Hematology

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