Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant

T. Murakami, F. L. Mastaglia, Walter G Bradley

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We studied protein synthesis in cervical anterior horn neurons in the "wobbler" mouse by measuring l-[4,5-3H]leucine incorporation using a light microscopic autoradiographic technique. Cytoplasmic incorporation of the isotope was significantly reduced not only in vacuolated nerve cells but also in those which were microscopically normal suggesting that impaired protein synthetic activity precedes the earliest morphologic changes seen with the light microscope. Isotope incorporation was reduced in small as well as large neurons suggesting that the disease process is not confined to α-motoneurons.

Original languageEnglish
Pages (from-to)423-432
Number of pages10
JournalExperimental Neurology
Volume67
Issue number2
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Anterior Horn Cells
Isotopes
Neurons
Light
Motor Neurons
Leucine
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant. / Murakami, T.; Mastaglia, F. L.; Bradley, Walter G.

In: Experimental Neurology, Vol. 67, No. 2, 01.01.1980, p. 423-432.

Research output: Contribution to journalArticle

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