Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant

T. Murakami, F. L. Mastaglia, W. G. Bradley

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We studied protein synthesis in cervical anterior horn neurons in the "wobbler" mouse by measuring l-[4,5-3H]leucine incorporation using a light microscopic autoradiographic technique. Cytoplasmic incorporation of the isotope was significantly reduced not only in vacuolated nerve cells but also in those which were microscopically normal suggesting that impaired protein synthetic activity precedes the earliest morphologic changes seen with the light microscope. Isotope incorporation was reduced in small as well as large neurons suggesting that the disease process is not confined to α-motoneurons.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalExperimental Neurology
Volume67
Issue number2
DOIs
StatePublished - Feb 1980
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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